Alpha‐lipoic acid ameliorates tauopathy‐induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor

Zarini-Gakiye, Elahe; Sanadgol, Nima; Parivar, Kazem; Vaezi, Gholamhassan

doi:10.1007/s11011-021-00679-7

Cited by 3 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, by suppressing the Tl-NF-κβ pathway, the Aβ42’s neuropathological activity decreases [ 185 ]. Furthermore, it was shown in Drosophila models that the increase of ROS can lead to tauopathies progression [ 186 – 189 ]. Pathogenic Tau and Aβ42 also have a negative effect on behavior, the regulation of neuroinflammatory genes, and the neurodegeneration in Drosophila .…”

Section: In Vitro and Preclinical Studies For Alzheimer’s And Parkins...mentioning

confidence: 99%

Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases

Balestri,

Sharma,

da Silva

et al. 2024

J Neuroinflammation

View full text Add to dashboard Cite

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and familial factors. These diseases have distinct pathologies and symptoms that are linked to specific cell populations in the brain. Notably, the immune system has been implicated in both diseases, with a particular focus on the dysfunction of microglia, the brain’s resident immune cells, contributing to neuronal loss and exacerbating symptoms. Researchers use models of the neuroimmune system to gain a deeper understanding of the physiological and biological aspects of these neurodegenerative diseases and how they progress. Several in vitro and in vivo models, including 2D cultures and animal models, have been utilized. Recently, advancements have been made in optimizing these existing models and developing 3D models and organ-on-a-chip systems, holding tremendous promise in accurately mimicking the intricate intracellular environment. As a result, these models represent a crucial breakthrough in the transformation of current treatments for PD and AD by offering potential for conducting long-term disease-based modeling for therapeutic testing, reducing reliance on animal models, and significantly improving cell viability compared to conventional 2D models. The application of 3D and organ-on-a-chip models in neurodegenerative disease research marks a prosperous step forward, providing a more realistic representation of the complex interactions within the neuroimmune system. Ultimately, these refined models of the neuroimmune system aim to aid in the quest to combat and mitigate the impact of debilitating neuroimmune diseases on patients and their families.

show abstract

Section: In Vitro and Preclinical Studies For Alzheimer’s And Parkins...mentioning

confidence: 99%