“…During the transition phase, loss of apical/basolateral polarity as a result of PKCζ inactivation [ 55 , 62 , 63 ], increases nuclear Yes-associated protein (Yap) levels [ 55 , 64 ], compensatory proliferation [ 62 , 65 , 66 ], cellular senescence [ 60 , 67 , 68 ], and cytoskeletal rearrangements [ 50 , 69 ], which contribute to long-term dysfunction. Changes in innervation and vasculature have been reported as early as 24 h post-IR [ 53 ], as well as at chronic time points [ 54 , 70 ]. Though inconsistently reported, fibrosis generally appears between 4 and 6 months following irradiation [ 1 , 44 , 71 ].…”