Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

Abstract

Objectives Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat. Methods Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0.4 mg/ml) or dexamethasone. Key findings As compared to group C, in OVA-sensitized rats, increases in WBC counts, levels of oxidant biomarkers and most pathological scores were observed while lymphocyte percentage and antioxidants levels decreased. Treatment with ALA (0.2 and 0.4 mg/ml) significantly reduced total WBC, NO 2 and NO 3 levels, interstitial fibrosis and emphysema compared to sensitized group. The higher dose of ALA also significantly decreased neutrophil, eosinophil, and monocyte counts, MDA levels and interstitial inflammation but increased lymphocyte counts, as well as antioxidants levels, compared to sensitized group. Dexamethasone administration led to a significant improvement of most factors compared to group S but had no effects on total WBC count, bleeding and epithelial damage. Conclusions Alpha-linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma.

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

“…ALA, a beneficial unsaturated fatty acid, can improve lipid distribution in vivo and inhibit inflammation and antioxidative stress. 38,39 In vitro studies have shown that the level of inflammatory factors. [41][42][43] These suggest that ALA has a direct impact on the inflammatory, which is mainly achieved by inhibiting iNOS and COX-2.…”

“…Another important pathway worth exploring is ALA metabolism, which includes ALA and 12,13‐EOTrE. ALA, a beneficial unsaturated fatty acid, can improve lipid distribution in vivo and inhibit inflammation and antioxidative stress 38,39 . In vitro studies have shown that ALA can inhibit the inflammatory characteristics of typical activated (M1) macrophages in LPS‐induced human THP‐1 cell line and reduce the production of IL‐1β, IL‐6, TNF‐α, and prostaglandin D2 40 .…”

Natural compounds against doxorubicin‐induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway

“…α-Linolenic acid (ALA), is a short chain n-3 fatty acid which is found in flaxseed oil and has beneficial properties for human health (Boskabady, Kaveh, Shakeri, Mohammadian Roshan, & Rezaee, 2019;L. Yang et al, 2005).…”

“…α‐Linolenic acid (ALA), is a short chain n‐3 fatty acid which is found in flaxseed oil and has beneficial properties for human health (Boskabady, Kaveh, Shakeri, Mohammadian Roshan, & Rezaee, 2019; L. Yang et al, 2005). Antioxidant, anti‐inflammatory, anti‐obesity, and anticancer activities of ALA were shown (da Silva Marineli et al, 2014; Ren & Chung, 2007).…”

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

“…Study groups consisted of 4 groups in total: Group 1 (Control group), Group 2 (OVA), Group 3 (Asthma + Dexa 0.25 mg/kg) and Group 4 (Asthma + Tyrosol 20 mg/kg). Establishing an experimental allergic asthma model and usage doses of dexamethasone were determined according to the literature (Boskabady et al 2019). The dosage of tyrosol was made in accordance with the study of Güvenç et al (Güvenç et al 2019).…”