Alpha-Glycerophosphate and Lactic Dehydrogenase Activities in Tissues of Thiamine-Deficient Rats

Eys, Jan Van

doi:10.1093/jn/73.4.403

Cited by 19 publications

(1 citation statement)

References 9 publications

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“…Pyruvate, not converted to acetyl CoA, is shunted through the lactate dehydrogenase enzyme (LDH), effectively increasing lactate output and lactic acid [71]. Research in the sixties found the activity and expression of LDH isoforms were highly influenced by thiamine availability [72,73], perhaps compensatory reactions to the changing ratio of pyruvate to lactate and NADH/NAD. Additionally, pyruvate metabolism is a critical player in oxygen homeostasis via its interactions with HIF proteins.…”

Section: Pyruvate Dehydrogenase Complexmentioning

confidence: 99%

Hiding in Plain Sight: Modern Thiamine Deficiency

Marrs

Lonsdale

2021

Cells

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Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways. It has a very short half-life, limited storage capacity, and is susceptible to degradation and depletion by a number of products that epitomize modern life, including environmental and pharmaceutical chemicals. The RDA for thiamine is 1.1–1.2 mg for adult females and males, respectively. With an average diet, even a poor one, it is not difficult to meet that daily requirement, and yet, measurable thiamine deficiency has been observed across multiple patient populations with incidence rates ranging from 20% to over 90% depending upon the study. This suggests that the RDA requirement may be insufficient to meet the demands of modern living. Inasmuch as thiamine deficiency syndromes pose great risk of chronic morbidity, and if left untreated, mortality, a more comprehensive understanding thiamine chemistry, relative to energy production, modern living, and disease, may prove useful.

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Section: Pyruvate Dehydrogenase Complexmentioning

confidence: 99%