Alpha–gamma interactions are disturbed in schizophrenia: A fusion of electroencephalography and functional magnetic resonance imaging

White, Thomas P.; Joseph, Verghese; O’Regan, Eileen; Head, Kevin; Francis, Susan T.; Liddle, Peter F.

doi:10.1016/j.clinph.2010.03.024

Cited by 28 publications

(20 citation statements)

References 57 publications

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“…A study by Spencer et al 46 reported that gamma-band power in auditory cortex (during an auditory task) was modulated by the phase of delta oscillations in a significantly lower degree in schizophrenic patients. This is complemented by White et al 47 who found reduced cross-frequency coupling between alpha and gamma bands in schizophrenia (see ref. 48 who could not observe decreases in cross-frequency coupling between theta and gamma; see refs 40,41,49 for reviews).…”

Section: Neuronal Findings In Schizophrenia Ib: Abnormal Balancementioning

confidence: 68%

Resting State Activity and the "Stream of Consciousness" in Schizophrenia--Neurophenomenal Hypotheses

Northoff

2014

Schizophrenia Bulletin

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Schizophrenia is a multifaceted disorder with various symptoms including auditory hallucinations, egodisturbances, passivity phenomena, and delusions. Recent neurobiological approaches have focused on, especially, the abnormal contents of consciousness, the "substantive parts" as James said, to associate them with the neural mechanisms related to sensory, motor, and cognitive functions, and the brain's underlying stimulus-induced or task-evoked activity. This leaves open, however, the neural mechanisms that provide the temporal linkage or glue between the various contents, the transitive parts that makes possible the "stream of consciousness." Interestingly, schizophrenic patients seem to suffer from abnormalities specifically in the "transitive parts" when they experience contents as temporally disconnected or fragmented which in phenomenological psychiatry has been described as "temporal fragmentation." The aim of this article is to develop so-called neurophenomenal hypothesis about the direct relationship between phenomenal features of the "stream of consciousness," the "transitive parts," and the specific neuronal mechanisms in schizophrenia as based on healthy subjects. Rather than emphasizing stimulus-induced and task-evoked activity and sensory and lateral prefrontal cortical regions as in neurocognitive approaches with their focus on the "substantive parts," the focus shifts here to the brain's intrinsic activity, its resting state activity, which may account for the temporal linkage or glue between the contents of consciousness, the transitive parts.

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Section: Neuronal Findings In Schizophrenia Ib: Abnormal Balancementioning

confidence: 68%

Resting State Activity and the "Stream of Consciousness" in Schizophrenia--Neurophenomenal Hypotheses

Northoff

2014

Schizophrenia Bulletin

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“…The potential relevance of abnormal cross-frequency interactions has only been investigated recently. Spencer et al [40] reported a reduced modulation of gamma-band SSEPs in the auditory cortex in schizophrenia through the phase of delta-oscillations while Liddle et al [41] observed decreased interactions between alpha-and gamma-band activity 9 during a somatosensory task. However, more recent results could not support impaired crossfrequency interactions between high and low frequency oscillations during auditory SSEPs [42].…”

Section: Neural Synchrony and Dysconnectivity In Schizophreniamentioning

confidence: 99%

Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia

Uhlhaas

2013

Current Opinion in Neurobiology

154

143

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“…102 Such an effect has also been observed in patients when attending to somatosensory stimuli. 103 In that study, 103 the reduced engagement of the salience network when attending to the external stimuli was also associated with poor deactivation of the DMN. More direct evidence for an impaired interaction between the salience network and the DMN comes from a functional connectivity analysis of independent components in the same sample.…”

Section: Functional Mri Studies Of Schizophreniamentioning

confidence: 99%

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

Palaniyappan

Liddle

2012

jpn

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472

443

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Alpha–gamma interactions are disturbed in schizophrenia: A fusion of electroencephalography and functional magnetic resonance imaging

Cited by 28 publications

References 57 publications

Resting State Activity and the "Stream of Consciousness" in Schizophrenia--Neurophenomenal Hypotheses

Resting State Activity and the "Stream of Consciousness" in Schizophrenia--Neurophenomenal Hypotheses

Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

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