Alpha-fetoprotein-producing transitional cell carcinoma of the urinary bladder: a case report

Abstract

We report a 76-year-old man with alpha-fetoprotein (AFP)-producing transitional cell carcinoma of the bladder. Although the serum level of AFP was 1,428 ng/ml, and he was anti-hepatitis C virus (anti-HCV) antibody-positive, liver tumors were not detected by either a computed tomography (CT) scan or a hepatic angiography. However, removal of a bladder tumor by transurethral resection and subsequent pathological examination revealed a grade III transitional cell carcinoma (TCC). Furthermore, immunohistochemical detection of AFP was diffuse-positive. After the tumor partially responded to concomitant chemoradiotherapy, the serum AFP levels decreased to 966 ng/ml. However, the tumor eventually progressed with multiple lung metastases, and serum AFP levels increased to 3,906 ng/ml. In conclusion, AFP-producing TCC of urinary bladder is rare, and the nature and pathophysiology remains unclear and warrants further investigation.

Somatic-Type Yolk Sac Tumor Arising as a Predominant Component of Bladder Urothelial Carcinoma

“…There are 9 previously reported cases of adenocarcinoma of the bladder in addition to 2 cases of urothelial carcinoma with AFP expression. 14-21 There are 4 previous reports from the renal pelvis with elevated serum AFP, 3 with glandular differentiation, and 2 with an associated urothelial carcinoma. 22-25 SALL4 positivity in urothelial carcinoma has also been described.…”

Alpha-fetoprotein producing Gastric carcinoma : A rare entity

“…However, AFP levels may be elevated in patients of primary gastric carcinoma 2 as well as other malignancies. [3][4][5][6][7][8][9] (Table 1) AFP producing gastric cancer (AFPGC) constitutes only about 2.7% to 8% of all gastric cancers. 10 They have high metastatic potential and possibility of vascular invasion, liver and lymph nodal metastases resulting in poor prognosis.…”

Συγκριτική Μελέτη Σχημάτων Κλασματοποίησης Της Ακτινοθεραπείας Στον Καρκίνο Της Ουροδόχου Κύστης

“…Καλοήθεις καταστάσεις και φλεγμονές των ουροφόρων οδών, μπορούν όμως να αυξήσουν τις τιμές του CEA [34]. H αλφα-φετοπρωτείνη [32] (AFP), το CA15-3 και το CA-19-9 δεν έχο υν διαγνωστική αξία στο ν καρκίνο της ο υρο δό χο υ κύστης. Το CA125 αποδείχθηκε ότι αυξάνεται περίπου στο 70% των ασθενών με μεταστατικό καρκίνωμα της ουροδόχου κύστης [24].…”