Alpha-Fetoprotein and Prolonged Neonatal Jaundice

Yablon, Olga; Mazur, O.

doi:10.24061/2413-4260.vi.4.22.2016.2

Cited by 1 publication

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“…The risk factors for the development of prolonged jaundice in newborns are complications during pregnancy and childbirth, the presence of gynecological and extragenital pathology in mothers , and onerous obstetric history, as well as prematurity, asphyxia, and cerebral ischemia [20][21][22]. The maternal age, weight, body mass index (BMI), numbers of pregnancies and prolonged delivery were significantly associated with bilirubin levels [23][24][25].…”

Section: Characteristicsmentioning

confidence: 99%

Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns

Mazur¹,

Yablon²,

Рубіна³

2019

Ukr.Biochem.J.

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Prolonged jaundice of newborns is a common pathology during the neonatal period. recently, there has been a tendency toward an increased number of newborns with prolonged jaundice with duration longer than 14 days of life. according to the polyetiologic nature of neonatal jaundice, it is necessary to investigate new diagnostic signs that can predict the development of prolonged jaundice in newborns and, allow identification of new methods of differential diagnosis of neonatal jaundice, as well as decrease the frequency of this pathology. the parameters of serum alpha-fetoprotein (aFP) content in newborns with prolonged jaundice were studied. the content of aFP in blood serum was 1.7 times higher in newborns with prolonged jaundice than in newborns with jaundice for up to 14 days of life: Me = 671.1 [Q1 = 479.9; Q3 = 815.03] ng/ml and Me = 401.0 [Q1 = 284.9; Q3 = 684.0] ng/ml, respectively (P < 0.05). the content of blood serum aFP in newborns with prolonged jaundice was higher for total serum bilirubin greater than 250 μmole/l: Me = 626.2 [Q1 = 454.7; Q3 = 793.2] ng/ml which was confirmed by a strong direct correlation relationship (r xy = 0.64, P < 0.05). The results of the ROC analysis confirmed that AFP ≥ 571.7 ng/ml can identify newborns with prolonged jaundice with a sensitivity of 74.2% and a specificity of 74.5%. The area under the curve (AUC) was 0.870 (95% CI 0.804, 0.937), which confirms the good quality of the AFP model ≥ 571.7 ng/ml.

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