Medical radioisotope 68 Ga / Proton and alpha-particle induced reactions / Excitation function / Integral yield / 66 Ga and 67 Ga contamination levels Summary. Experimentally measured cross sections are presented for the nat Cu(α, xn) 66,67,68 Ga and 68 Zn( p, xn) 67,68 Ga nuclear processes up to 36 and 20 MeV, respectively. Based on these results and the reliable cross section data available in the literature, the possible thick target yields were also calculated. Two different 68 Ga production routes (Cu + α and Zn + p) are discussed in detail, especially with regard to the 66 Ga and 67 Ga contamination levels as a function of the target enrichment level and the incident bombarding energies. Both processes can be used for in-house 68 Ga production with low (< 1%) 66 Ga and/or 67 Ga EOB contamination using enriched 68 Zn (> 80%) or 65 Cu (> 95%) target. The maximum available yield on 100% enriched 68 Zn and 65 Cu (irradiation time: 2.25 h; bombarding energy: E p = 20 MeV and E α = 18 MeV) is 352.45 mCi/µA (13.04 GBq/µA) and 14.28 mCi/µA (528.36 MBq/µA), respectively.