alpha-BLOCKERS FOR THE TREATMENT OF CHRONIC PROSTATITIS IN COMBINATION WITH ANTIBIOTICS

Barbalias, George A.; Nikiforidis, George; Liatsikos, E.

doi:10.1016/s0022-5347(01)63761-3

Cited by 134 publications

(43 citation statements)

References 15 publications

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“…34 Recently it has been reported that the use of alphablockers in combination with antibiotics was more ef®ca-cious than antibiotics alone. 40 Direct injection of antimicrobial agents into the prostatic tissue has been suggested in the past, but has not achieved widespread approval, 41 while recently the anal submucosal route of antibiotics administration has been proposed for the treatment of chronic bacterial prostatitis, but the results of this report have not been con®rmed by others yet. 42 In cases of CBP with prominent prostatic calci®cation, surgery has been suggested, especially if there are a large number of prostatic calculi.…”

Section: Treatmentmentioning

confidence: 88%

“…Barbalias et al, 40 based on their video-urodynamic ®nd-ings during micturition (distal narrowing of the prostatic and membranous urethral segment) in patients suffering from`painful male urethral syndrome', treated this group of patients with alpha-blockers. The majority of them responded favorably to treatment, but maintained the good results only with a long-term treatment schedule (up to eight months).…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Prostatitis

Theodorou

Becopoulos

1999

Prostate Cancer Prostatic Dis

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The objective of this article is to present a detailed review of the international literature concerning both the already established and the most recent information about clinical picture, aetiology, classi®cation, diagnosis and treatment of prostatitis.The symptomatology of the condition is non-speci®c and requires a wide spectrum of diagnostic tools in order the clinician be able to reach a ®rm conclusion. A novel classi®cation system is outlined, with already established international reputation.The treatment of the various chronic types is often empirical and the available therapies need controlled studies in order to achieve an established status in Urologist's armamentarium.Finally it is emphasized that continuous research addressing to aetiology, pathogenesis, diagnosis and treatment is of paramount importance in answering questions and shedding light on this obscure syndrome.

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Section: Treatmentmentioning

confidence: 88%

Section: Treatmentmentioning

confidence: 99%

Prostatitis

Theodorou

Becopoulos

1999

Prostate Cancer Prostatic Dis

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“…Besides ef®cacy, safety, blood-pressure effects, therapeutic dose range, and cost, other considerations of alpha-blockers should include their effects on plasma lipids, 80 apoptosis, 81,82 erectile function, 83,84 and prostatitis. 85 In the future, the development of a true subtypeselective alpha-1 antagonist may lead to signi®cant advances in the medical treatment of BPH. It remains to be seen whether a subtype-selective agent will be able to reduce side effects while maintaining ef®cacy.…”

Section: Discussionmentioning

confidence: 99%

Alpha–1–adrenoceptor blockade in the treatment of benign prostatic hyperplasia

Lowe

1999

Prostate Cancer Prostatic Dis

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In light of the growing interest in the concept of`uroselectivity' and in the increased worldwide use of alpha-blockers for benign prostatic hyperplasia (BPH), this review evaluates the relative bene®ts of various alpha-blocking agents in the treatment of BPH. The pharmacological and physiological selectivity as well as the clinical ef®cacy and safety of alfuzosin, doxazosin (Cardura 1 ), tamsulosin (Flomax 1 ), and terazosin (Hytrin 1 ) are compared. In reviewing ef®cacy and safety, emphasis is given to 17 placebo-controlled, doubleblind trials of these alpha-blockers published in peer-reviewed journals. This review also considers long-term data, effects on blood pressure, costs, and dose ranges.

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“…Combination therapy [30] included a daily dose of the alpha-adrenoceptor blocker alfuzosin (10 mg, extended-release formulation) [33] and a S. repens extract (640 mg day −1 ). This therapeutic regimen was administered for 6 weeks to all patients.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

Magri¹,

Wagenlehner²,

Montanari³

et al. 2009

Asian J Androl

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The significance and diagnostic value of semen analysis in chronic bacterial prostatitis has been extensively debated and remains controversial. To investigate the diagnostic relevance of semen culture in the bacteriological workup of prostatitis patients, we retrospectively analyzed a clinical database of 696 symptomatic patients. All patients were routinely subjected to a four-glass test, followed by semen culture and analysis. This allowed to dissect from the database three different diagnostic scenarios, and to compare the 'two-glass' pre-/post-massage test and the standard 'four-glass' test with a 'five-glass' test (four-glass plus post-VB3 semen culture). The 'five-glass' test showed 3.6-or 6.5-fold increases in relative sensitivity and lesser reductions (-13.2% or -14.7%) in relative specificity for traditional uropathogens (TUs) compared with the four-glass or two-glass test, respectively. The area under the ROC curve and Jouden's index were increased, whereas positive and negative likelihood ratios were lower than comparators, indicating that the 'five-glass' assay may be superior in confirming the negative outcome of both standard tests. The five-, four-, and two-glass tests detected TUs (Enterobacteriaceae, Enterococci, etc.) in 120, 33, and 20 patients and unusual pathogens (Streptococci, other Gram-positive species, Mycoplasmata, and others) in 130, 56, and 45 patients, respectively. When patients were subjected to pharmacological treatment, including a combination of a fluoroquinolone and a macrolide, no differences in eradication rates were observed between groups diagnosed with different tests, irrespective of pathogen category. Eradication was associated with long-term sign/symptom remission; no significant intergroup differences in sign/symptom scores were observed throughout a 24-month off-therapy follow-up period. In conclusion, our data support the usefulness of semen analysis in the diagnostic workup of prostatitis patients when this test is used to complement the four-glass Meares and Stamey test. Improvement of microbiological assays conveys important diagnostic and therapeutic implications.

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alpha-BLOCKERS FOR THE TREATMENT OF CHRONIC PROSTATITIS IN COMBINATION WITH ANTIBIOTICS

Cited by 134 publications

References 15 publications

Prostatitis

Prostatitis

Alpha–1–adrenoceptor blockade in the treatment of benign prostatic hyperplasia

Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications

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