Alpha‐Beta Phase Transformation in Tricalcium Phosphate (TCP)Ceramics: Effect of Mg
            <sup>2+</sup>
            Doping

Frasnelli, Matteo; Sglavo, Vincenzo M.

doi:10.1002/9781119211624.ch6

Cited by 1 publication

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References 16 publications

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“…, a small part of Ca 2? ions in b-TCP crystals were instead, the three Mg-containing groups also produced calcium magnesium phosphate (Ca 2.86 Mg 0.14 (-PO 4 ) 2 ), which was a kind of b-TCMP (Mg-substituted beta-tricalcium phosphate) [40].…”

Section: Effects Of Sustained Release Of Mg 21 On Angiogenesis In Huvecsmentioning

confidence: 99%

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

Zhang

et al. 2019

Tissue Eng Regen Med

115

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BACKGROUND: Three-dimensional (3D) printed bone tissue engineering scaffolds have been widely used in research and clinical applications. b-TCP is a biomaterial commonly used in bone tissue engineering to treat bone defects, and its multifunctionality can be achieved by co-doping different metal ions. Magnesium doping in biomaterials has been shown to alter physicochemical properties of cells and enhance osteogenesis. METHODS: A series of Mg-doped TCP scaffolds were manufactured by using cryogenic 3D printing technology and sintering. The characteristics of the porous scaffolds, such as microstructure, chemical composition, mechanical properties, apparent porosity, etc., were examined. To further study the role of magnesium ions in simultaneously inducing osteogenesis and angiogenesis, human bone marrow mesenchymal stem cells (hBMSCs) and human umblical vein endothelial cells (HUVECs) were cultured in scaffold extracts to investigate cell proliferation, viability, and expression of osteogenic and angiogenic genes. RESULTS: The results showed that Mg-doped TCP scaffolds have the advantages of precise design, interconnected porous structure, and similar compressive strength to natural cancellous bone. hBMSCs and HUVECs exhibit high proliferation rate, cell morphology and viability in a certain amount of Mg 2? . In addition, this concentration of magnesium can also increase the expression levels of osteogenic and angiogenic biomarkers. CONCLUSION: A certain concentration of magnesium ions plays an important role in new bone regeneration and reconstruction. It can be used as a simple and effective method to enhance the osteogenesis and angiogenesis of bioceramic scaffolds, and support the development of biomaterials and bone tissue engineering scaffolds. Keywords 3D porous scaffolds Á Ion doping Á Magnesium ions Á Osteogenesis Á Angiogenesis Yifan Gu and Jing Zhang contributed equally to this work.

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Section: Effects Of Sustained Release Of Mg 21 On Angiogenesis In Huvecsmentioning

confidence: 99%

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

Zhang

et al. 2019

Tissue Eng Regen Med

115

View full text Add to dashboard Cite

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Alpha‐Beta Phase Transformation in Tricalcium Phosphate (TCP)Ceramics: Effect of Mg ²⁺ Doping

Cited by 1 publication

References 16 publications

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

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Alpha‐Beta Phase Transformation in Tricalcium Phosphate (TCP)Ceramics: Effect of Mg 2+ Doping

Cited by 1 publication

References 16 publications

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

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Alpha‐Beta Phase Transformation in Tricalcium Phosphate (TCP)Ceramics: Effect of Mg ²⁺ Doping