Alpha B-crystallin C-802G polymorphism and colorectal cancer susceptibility and clinical outcome in Chinese population

Wu, Xihan; Zheng, Yuanzheng; Han, Bin; Wang, Ke

doi:10.1038/s41598-018-29589-y

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…(2018) studied CRYAB C-802G (rs14133) polymorphism in association with colorectal cancer risk and survival. CG/GG genotype carriers were associated with increased risk of CRC in comparison of CC genotype carriers [101].…”

Section: Annals Of Agricultural and Environmental Medicinementioning

confidence: 89%

αB-crystallin as a promising target in pathological conditions – A review

Maksimiuk

Sobiborowicz

Tuzimek

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. αB-crystallin belongs to the ubiquitous family of small heat-shock proteins. It was discovered as a physiological protein of the eye lens, maintaining its liquid-like property. Furthermore, αB-crystallin was proved to playa bipolar role in both physiological and pathophysiological conditions. This review discusses current knowledge about the biology and genetics of αB-crystallin, and summarizes recent advances in understanding its role in ophthalmic and neurological disorders, as well as breast cancer, renal cancer and other malignancies. State of knowledge. α-crystallins are established as important elements of the protein quality control network, and consequently their defects are related to multiple human diseases. New studies highlight αB-crystallin's involvement in proliferative diabetic retinopathy angiogenesis and point out its therapeutic potential in age-related macular degeneration. αB-crystallin is thought to be associated with the disease-causing protein aggregates, leading to its connection with such neurological disturbances as anaplastic astrocytoma, Parkinson disease, aging deficits in the peripheral nervous system and multiple sclerosis. In breast cancer, it was proven to be a marker of aggressive behaviur and cerebral metastases. Strong expression of αB-crystallin promoted growth and migration of clear cell renal cell carcinoma cells and was correlated with lower overall survival rate. Considering other malignancies, its various roles were established in colorectal and gastric cancers, head and neck squamous cell carcinomas and osteosarcomas. Conclusions. Further studies concerning αB-crystallin seem to be enormously promising, as they might improve our understanding of common human pathologies as well as contemporary diagnostics and treatment.

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Section: Annals Of Agricultural and Environmental Medicinementioning

confidence: 89%

αB-crystallin as a promising target in pathological conditions – A review

Maksimiuk

Sobiborowicz

Tuzimek

et al. 2020

Ann Agric Environ Med.

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“…Considering the potential association of SNPs with congenital cataract and the dearth of information on genetic association studies using intronic SNPs,[ 38 39 ] the present study was performed to understand the distribution of intronic SNPs rs3788059 ( CRYAA ), rs2070894 ( CRYAB ), rs2071861 ( CRYBA4 ), rs5752083 ( CRYBB2 ), and rs5996863 ( CRYBB2 ) in congenital cataracts and normal healthy controls. Although association studies using these markers have never been reported in congenital cataracts, studies on rs2070894 concerning colorectal and oral cancer[ 40 41 ] and rs2071861 concerning high myopia[ 42 43 ] have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…(2011)[ 40 ] and Wu et al . (2018)[ 41 ] evaluated the association of CRYAB -rs2070894 polymorphism with colorectal and oral cancer, respectively, and did not report any significant association of the allele or genotype with the disease. The distribution of the “AC” genotype of CRYBB2 -rs5752083 was found to be significantly less in cases than in controls.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the association of intronic single nucleotide polymorphisms of crystallin gene family with congenital cataract

Nair

Sankaranarayanan²,

Vasavada³

2021

Indian Journal of Ophthalmology

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Purpose: Introns play an important role in gene regulation and expression. Single nucleotide polymorphisms (SNPs) in introns have the potential to cause disease and alter the genotype–phenotype association. Hence, this study aimed to decipher the association of SNPs in the introns of the crystallin gene in congenital cataracts. Methods: SNPs in the introns of crystallin gene family – CRYAA (rs3788059), CRYAB (rs2070894), CRYBA4 (rs2071861), and CRYBB2 (rs5752083, rs5996863) – were genotyped in 248 participants consisting of 141 congenital cataracts and 107 healthy controls by allele-specific oligonucleotide polymerase chain reaction method. Around 10% of samples for each SNPs were sequenced to confirm the genotypes. The allele, genotype, and haplotype frequency were evaluated by the SHEsis online tool. Results: Using dominant model, the “A” allele of rs3788059 was found to have an increased risk toward congenital cataract development whereas the “G” allele was found to be protective (AA + AG vs. GG; odds ratio [ OR ] 95% confidence interval [CI] = 3.73 [1.71, 8.15], P = 0.0009). The “A” allele of both rs2070894 (AA + AG vs. GG; OR [95% CI] = 0.49 [0.29, 0.84], P = 0.012) and rs5752083 (AA + AC vs. CC; OR [95% CI] = 0.25 [0.08, 0.76], P = 0.016) were suggested to have a protective role by the dominant model. The A-C-T haplotype (rs2071861, rs5752083, and rs5996863) was found to be a significant risk factor for the development of congenital cataract. Conclusion: Intronic SNPs in crystallin genes may play a role in the predisposition toward congenital cataract. However, the present findings need to be replicated in a large cohort with more number of samples.

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“…In summary, CRYAB may trigger the EMT in CRC by activating the ERK signaling pathway and is a potential tumor biomarker for CRC diagnosis and prognosis 108. Also, CG/GG at CRYAB C-802G is correlated with CRC susceptibility, and this polymorphism may be a useful marker for the clinical outcome of CRC 112…”

Section: Cryab In Diseasesmentioning

confidence: 98%

<p>Progression of the role of CRYAB in signaling pathways and cancers</p>

Zhang

Liu

et al. 2019

OTT

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CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases and even cancers, for example, breast cancer, lung cancer, prostate cancer, and ovarian cancer. In addition, CRYAB proteins are involved in a variety of signaling pathways including apoptosis, inflammation, and oxidative stress. This review summarizes the recent progress concerning the role of CRYAB in signaling pathways and diseases. Therefore, the role of CRYAB in signaling pathways and cancers is urgently needed. This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease.

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Alpha B-crystallin C-802G polymorphism and colorectal cancer susceptibility and clinical outcome in Chinese population

Cited by 5 publications

References 20 publications

αB-crystallin as a promising target in pathological conditions – A review

αB-crystallin as a promising target in pathological conditions – A review

Deciphering the association of intronic single nucleotide polymorphisms of crystallin gene family with congenital cataract

<p>Progression of the role of CRYAB in signaling pathways and cancers</p>

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