1980
DOI: 10.1152/jappl.1980.48.5.759
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alpha-Adrenergic control of intestinal circulation in heat-stressed baboons

Abstract: The mechanisms involved in producing intestinal vasoconstriction during a hyperthermia-producing intestinal vasoconstriction during a hyperthermia-producing environmental heat stress are unknown. Five conscious baboons (Papio anubis), each with chronically implanted catheters and a flow probe around the superior mesenteric artery, were subjected to environmental heating (Ta 40-45 degrees C) to raise their arterial blood temperature (Tbl) 2.0-2.6 degrees C to approximately 39.5 degrees C. Accompanying the gradu… Show more

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Cited by 26 publications
(13 citation statements)
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“…2) indicates that activation of the sympathetic nervous system is a primary vasoconstrictor mechanism responsible for reducing celiac blood flow during acute heat exposure in fed cockerels. The vascular responses following phenoxybenzamine infusion during the thermoneutral and heat-exposure periods were similar to changes of superior mesenteric blood flow, resistance, and arterial pressure after a-receptor blockade in baboons (Proppe, 1980). A decrease in MBP during the thermoneutral period prior to heat exposure implicates a suppression of systemic vasomotor tone following a-receptor blockade.…”
Section: Discussionmentioning
confidence: 59%
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“…2) indicates that activation of the sympathetic nervous system is a primary vasoconstrictor mechanism responsible for reducing celiac blood flow during acute heat exposure in fed cockerels. The vascular responses following phenoxybenzamine infusion during the thermoneutral and heat-exposure periods were similar to changes of superior mesenteric blood flow, resistance, and arterial pressure after a-receptor blockade in baboons (Proppe, 1980). A decrease in MBP during the thermoneutral period prior to heat exposure implicates a suppression of systemic vasomotor tone following a-receptor blockade.…”
Section: Discussionmentioning
confidence: 59%
“…A decrease in MBP during the thermoneutral period prior to heat exposure implicates a suppression of systemic vasomotor tone following a-receptor blockade. Alpha-receptor blockade produced cutaneous vasodilation (Wyss and Rowell, 1976;Rowell, 1983) and a 1 C decrease in blood temperature (Proppe, 1980) in baboons. Similary, a .6 C reduction in T r associated with a decrease in celiac MBF in the present study may indicate a relaxation of systemic vasomotor tone in response to areceptor blockade.…”
Section: Discussionmentioning
confidence: 96%
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“…Heat exposure reduces intestinal blood flow in sheep (Hales, 1973) baboons (Hales et al, 1979;Proppe, 1980), and chickens (Wolfensen et al, 1981). Depressed gastrointestinal blood flow may impair energy assimilation and contribute to poor growth performance characteristic of heat-exposed animals, because fat soluble compound absorption is blood-flow dependent (Lundgren and Jodal, 1975).…”
Section: Introductionmentioning
confidence: 99%
“…This visceral vasoconstriction is mediated by a-adrenergic mechanisms (Proppe, 1980;Kregel and Gisolfi, 1989; and under mild to moderate heat stress helps maintain arterial blood pressure. Severe hyperthermia, however, may lead to the medical emergency referred to as heat stroke which is marked by a precipitous fall in mean arterial blood pressure.…”
mentioning
confidence: 99%