Alpha-2 Adrenergic and Imidazoline Receptor Agonists: Clonidine, Dexmedetomidine, and Related Antihypertensives, Decongestants, and Sedatives

Tomassoni, Anthony J.

doi:10.1007/978-3-319-20790-2_27-1

Cited by 1 publication

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“…Clonidine is a first-generation antihypertensive agent that suppresses sympathetic outflow from the central nervous system by acting on α 2 -adrenergic and I 1 -imidazoline receptors [ 1 – 3 ]. After clonidine, several central antihypertensive agents with different properties have been developed.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of the central versus peripheral effect of intravenous clonidine using baroreflex equilibrium diagrams

et al. 2021

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Clonidine is a first-generation central antihypertensive that reduces sympathetic nerve activity (SNA). Although clonidine also exerts peripheral vasoconstriction, the extent to which this vasoconstriction offsets the centrally mediated arterial pressure (AP)-lowering effect remains unknown. In anesthetized rats (n = 8), we examined SNA and AP responses to stepwise changes in carotid sinus pressure under control conditions and after intravenous low-dose (2 μg/kg) and high-dose clonidine (5 μg/kg). In the baroreflex equilibrium diagram analysis, the operating-point AP under the control condition was 115.2 (108.5–127.7) mmHg [median (25th–75th percentile range)]. While the operating-point AP after low-dose clonidine was not significantly different with or without the peripheral effect, the operating-point AP after high-dose clonidine was higher with the peripheral effect than without [81.3 (76.2–98.2) mmHg vs. 70.7 (57.7–96.9), P < 0.05]. The vasoconstrictive effect of clonidine partly offset the centrally mediated AP-lowering effect after high-dose administration.

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Section: Introductionmentioning

confidence: 99%