Alpha-1 Blockade Pharmacotherapy
in Primitive Psychogenic
Premature Ejaculation Resistant
to Psychotherapy

Cavallini, Giorgio

doi:10.1159/000475036

Cited by 79 publications

(60 citation statements)

References 18 publications

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“…These reports comprised the use of anesthetic ointments, 12,26,27,[29][30][31][32][33][34][35][36][37] neuroleptics, 20,22,[38][39][40][41][42] monoamine-oxidase inhibitors, 16,43 sympatholytic drugs, 18,19,[44][45][46] antibiotics, 47,48 and a group of miscellaneous agents 13,14,21,[49][50][51] (Table 1). Between 1973 and 2003, there have been 35 studies 15,17,23-25,60-79,80,81 on daily treatment with clomipramine, a tricyclic antidepressant, and on SSRIs (Table 2).…”

Section: General Results Of Reviewmentioning

confidence: 99%

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

et al. 2004

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The aim of this systematic review and meta-analysis is to evaluate whether the design and methodology of drug-treatment studies of premature ejaculation affect the efficacy outcome differently. Therefore, methodological, design and efficacy data from 79 studies (3034 males), published between 1943 and 2003, are reviewed. A meta-analysis is performed on 43 selective serotonin reuptake inhibitors (SSRIs) and clomipramine studies (1514 males), published between 1973 and 2003; these studies were pooled to provide a summary variance-weighted effect size. The antidepressant-induced percentage increase of the intravaginal ejaculation latency time (IELT) was calculated and examined against various methodological items. A significant difference in efficacy between SSRIs was observed. Using daily treatment, paroxetine appeared more effective than the other SSRIs. Retrospective use of a questionnaire, subjective reports, single-blind and open study designs generate far greater variability of ejaculation time both at baseline and during active drug treatment than real time assessment by stopwatch. In conclusion, at daily treatment, the overall efficacy of paroxetine, clomipramine, sertraline and fluoxetine is comparable, but paroxetine exerts the strongest ejaculation delay. Only eight (18.5%) studies on antidepressant treatment fulfilled all criteria used in evidence-based medicine, for example, randomised, double-blind studies with prospective real time (stopwatch) assessment of the IELT at each intercourse. Single-blind studies, open designs, retrospective reporting, or the use of a questionnaire to assess ejaculation time should be avoided.

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Section: General Results Of Reviewmentioning

confidence: 99%

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

et al. 2004

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“…Only a few clinical studies have been designed to assess the potential of ␣ 1 -adrenoreceptor antagonists in PE (Beretta et al, 1986;Cavallini, 1995;Başar et al, 2005). PE symptoms were improved in 50 to 67% of the subjects.…”

Section: Other Treatmentsmentioning

confidence: 99%

Pharmacology for the Treatment of Premature Ejaculation

Giuliano

Clément

2012

Pharmacol Rev

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“…Although the a-blockers included in this study served as a positive, internal control to confirm the viability of this modified rat model, Cavallini demonstrated the therapeutic efficacy of a1-adrenergic blockers (alphuzosin and terazosin) for premature ejaculation in a double-blind, placebo-controlled, crossover clinical trial. 20 However, to explain the fact that the in vivo effect of a-blockers in these experiments far exceeds their clinical efficacy, experimental modifications are needed to evaluate the expulsion phase of ejaculation. Development of such in vivo animal models underscore the need for more focused research in the elucidation of the physiology of ejaculation and highlight the importance of a robust model for the investigation of therapeutic efficacy for pharmacological agents in the treatment of premature ejaculation.…”

Section: Discussionmentioning

confidence: 99%

In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously

Paick

2004

Int J Impot Res

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This study presents a modified in vivo model in which the intraluminal pressures of the seminal vesicle and vas deferens can be measured simultaneously. Male Sprague-Dawley rats were grouped based on agent administered: serotonin, clomipramine, fluoxetine, sertraline, paroxetine, prazosin, terazosin, and tamsulosin. The control responses to hypogastric nerve stimulation (HNS) were recorded in each animal, and HNS was repeated after each drug administration. Serotonergic agents resulted in concentration-dependent inhibition of the HNS-induced seminal vesicle pressure increases (clomipramine4serotonin4fluoxetine4sertralineEparoxetine). On the other hand, only serotonin and clomipramine significantly inhibited vasal pressure responses. a-Adrenergic blockers inhibited both intraluminal pressure responses in a concentration-dependent manner. This model illustrates the importance of the hypogastric nerve for the stimulation of the seminal tract, with attention focused on the seminal vesicle. This model may be useful for the evaluation of drugs for the treatment of premature ejaculation.

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Alpha-1 Blockade Pharmacotherapy in Primitive Psychogenic Premature Ejaculation Resistant to Psychotherapy

Cited by 79 publications

References 18 publications

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

Pharmacology for the Treatment of Premature Ejaculation

In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously

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