Abstract:Serum α1-antitrypsin (α1AT) levels and protease inhibitor (PI) phenotypes were determined in 176 patients with bronchial asthma. The results were compared with 121 nonasthmatic controls. In the bronchial asthma group, 144 patients (81.8%) had M phenotype, compared to 118 (97.5%) in the controls. Severe deficiency of α1AT associated with Z phenotype were found in 18 patients (10%), compared to 2 (1.6%) in the controls. Intermediate deficiency associated with MZ and FZ phenotypes… Show more
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