Abstract:The hepatic glucose fasting response is gaining traction as a therapeutic pathway to enhance hepatic and wholehost metabolism. However, the mechanisms underlying these metabolic effects remain unclear. Here, we demonstrate the lipoxygenase, ALOXE3, is a novel effector of the therapeutic fasting response. We show that ALOXE3 is activated during fasting, glucose withdrawal, or trehalose/trehalose analogue treatment. Hepatocytespecific ALOXE3 expression reduced weight gain and hepatic steatosis in diet-induced an… Show more
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