Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G<sub>2</sub>/M cell cycle arrest and inhibition of GROα expression

Aloperine is an alkaloid found in the seeds and leaves of the medicinal plant Sophora alopecuroides L. It has been used as herbal medicine in China for centuries due to its potent anti-inflammatory, antioxidant, antibacterial, and antiviral properties. Recently, aloperine has been widely investigated for its therapeutic activities. Aloperine is proven to be an effective therapeutic agent against many human pathological conditions, including cancer, viral diseases, and cardiovascular and inflammatory disorders. Aloperine is reported to exert therapeutic effects through triggering various biological processes, including cell cycle arrest, apoptosis, autophagy, suppressing cell migration, and invasion. It has also been found to be associated with the modulation of various signaling pathways in different diseases. In this review, we summarize the most recent knowledge on the modulatory effects of aloperine on various critical biological processes and signaling mechanisms, including the PI3K, Akt, NF-κB, Ras, and Nrf2 pathways. These data demonstrate that aloperine is a promising therapeutic candidate. Being a potent modulator of signaling mechanisms, aloperine can be employed in clinical settings to treat various human disorders in the future.

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Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G₂/M cell cycle arrest and inhibition of GROα expression

Abstract: Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G 2 /M cell cycle arrest and inhibition of GROα expression,

Cited by 3 publications

References 26 publications

The recent development of topical nanoparticles for annihilating skin cancer

The recent development of topical nanoparticles for annihilating skin cancer

Design, Synthesis and Biological Evaluation of Aloperine Derivatives as Potential Anticancer Agents

Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases

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Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G2/M cell cycle arrest and inhibition of GROα expression

Abstract: Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G 2 /M cell cycle arrest and inhibition of GROα expression,

Cited by 3 publications

References 26 publications

The recent development of topical nanoparticles for annihilating skin cancer

The recent development of topical nanoparticles for annihilating skin cancer

Design, Synthesis and Biological Evaluation of Aloperine Derivatives as Potential Anticancer Agents

Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases

Contact Info

Product

Resources

About

Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G₂/M cell cycle arrest and inhibition of GROα expression