Alopecic and Aseptic Nodules of the Scalp: First Report in South America and Second in America

Abstract

Alopecic and aseptic nodules of the scalp, also named pseudocysts of the scalp, are a relatively new, little-known, and for sure underdiagnosed disease. It affects mostly young men and is characterized by a solitary or a few dome-shaped nodules accompanied by nonscarring alopecia, deep inflammatory infiltration in the skin biopsy specimen, and, in most cases, granulomas. It has a good response to doxycycline, intralesional corticosteroids, or drainage/aspiration of the lesion. We present a case report and a summary of the published cases.

Alopecic and aseptic nodules of the scalp: A new case with a systematic review of the literature

“…The staining and the microbiological cultures for fungi and bacteria were always negative 1,2 . There is an increasing number of reports describing AANS suggesting that this entity may be not so rare and probably underdiagnosed 3‐9 . A similar nosological entity, known as pseudocyst of the scalp (PCS), in different Asian case reports was previously described 10,11 .…”

Alopecic and aseptic nodules of the scalp: A new entity or a minor form of dissecting cellulitis?

“…The condition responded well to oral doxycycline therapy with the recovery of hair. Subsequent single case reports and case series did not add any new insight of pertinence to the nomenclature and nosology of the condition,[ 6 7 8 9 10 11 12 13 14 15 16 ] including Heymann's latest comment in Dermatology World Insights and Inquiries. [ 17 ] Under the line, the authors state that the condition is rare, probably underreported, and its etiopathogenesis poorly understood.…”

Alopecic and aseptic nodules of the scalp: an underdiagnosed entity

“…This underdiagnosed entity requires careful clinical consideration to make an accurate diagnosis and adequately manage patients. AANS should be differentiated from other scalp lesions such as inflamed trichilemmal cysts, alopecia areata, bacterial folliculitis, dissecting cellulitis of the scalp, and metastatic nodules [ 2 ].…”