Alopecia Neoplastica due to Metastatic Colon Adenocarcinoma

Gül, Ülker; Kılıç, Arzu; Akbaş, Ayşe; Aslan, Erkan; Demiriz, Murat

doi:10.2340/00015555-0166

Cited by 12 publications

(15 citation statements)

References 8 publications

(15 reference statements)

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“…The clinical spectrum of cutaneous metastases furthermore comprised bullous and papulo-squamous lesions, scarred plaques, and pigmented tumour nodes. Alopecia neoplastica was rarely attributed to mamma-, lung-, colon-and renal cell-carcinoma (Gul et al 2007;Wagner 2007). The majority of skin metastases remained asymptomatic, but sometimes they cause itching and tension (Stein and Spencer 2002) and in advanced stages pain.…”

Section: Clinical Picturementioning

confidence: 97%

Cutaneous metastases of visceral tumours: a review

Nashan

Müller

Braun‐Falco

et al. 2008

J Cancer Res Clin Oncol

116

136

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Section: Clinical Picturementioning

confidence: 97%

Cutaneous metastases of visceral tumours: a review

Nashan

Müller

Braun‐Falco

et al. 2008

J Cancer Res Clin Oncol

116

136

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“…Their typical locations are the perineal region and abdominal wall, particularly in the periumbilical area, being a frequent cause of the so-called Sister Mary Joseph nodule 98,99 (Fig. 101 In rare instances, cutaneous metastases from colorectal carcinoma show other appearances, including erysipelas-like lesions, 102 alopecia neoplastica, 103 and zosteriform pattern. Skin involvement of colorectal carcinoma seems to favor sites of previous incisions, as a colostomy site, 100 but sometimes the skin of scalp or face may be affected, and in these cases, the nodules have cystic appearance.…”

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the primary site of malignancy, gastrointestinal (GI) tract accounted for 24.4% (30/123), breast for 17.9% (22/123) of cases, kidney for 8.1% (10/123), lung for 7.3% (9/123), thyroid for 7.3% (9/123), uterus for 6.5% (8/123), central nervous system (CNS) for 6.5% (8/123), liver for 3.3% (4/123) and other anatomic areas for 18.7% (23/123) of cases …”

Section: Resultsmentioning

confidence: 99%

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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Alopecia Neoplastica due to Metastatic Colon Adenocarcinoma

Cited by 12 publications

References 8 publications

Cutaneous metastases of visceral tumours: a review

Cutaneous metastases of visceral tumours: a review

Cutaneous Metastases From Internal Malignancies

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

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