Alopecia in Breastfed Infant Possibly Due to Mother Getting Valproate

Govindan, Karthika; Mandadi, Gowri Devi

doi:10.1007/s12098-020-03390-0

Cited by 4 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases reported, valproate in breastmilk did not cause serious adverse effects in infants. In rare cases, some infants occurred side effects such as drowsiness, alopecia, petechiae, thrombocytopenia, anemia, and mild hematuria, and these symptoms gradually improve after drug withdrawal ( 79 , 80 ).…”

Section: Metabolic Pathway Of Asms and The Influence Of Asms In Human...mentioning

confidence: 99%

Management of anti-seizure medications in lactating women with epilepsy

et al. 2022

View full text Add to dashboard Cite

Epilepsy is a common neurological disease. At present, there are about 70 million epilepsy patients in the world, half of them are women, and 30–40% of women with epilepsy are of childbearing potential. Patients with epilepsy who are of childbearing potential face more challenges, such as seizures caused by hormonal fluctuations and the risk of adverse effects on the mother and baby from taking anti-seizure medications (ASMs). Breast milk is one of the best gifts that a mother can give her baby, and breastfeeding can bring more benefits to the baby. Compared with healthy people, people with epilepsy have more concerns about breastfeeding because they are worried that ASMs in their milk will affect the growth and development of the baby, and they are always faced with the dilemma of whether to breastfeed after childbirth. Regarding, whether women with epilepsy can breastfeed while taking ASMs, and whether breastfeeding will adversely affect the baby is still an important topic of concern for patients and doctors. This article reviews the existing research on breastfeeding-related issues in women with epilepsy to guide clinical practice, and improve the breastfeeding compliance of women with epilepsy.

show abstract

Section: Metabolic Pathway Of Asms and The Influence Of Asms In Human...mentioning

confidence: 99%

Management of anti-seizure medications in lactating women with epilepsy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hair changes are usually evident after 3 to 6 months of starting valproate (Wilting et al, 2007). When given during pregnancy, the newborn may have aplasia cutis congenita of the scalp and may present with a sharply circumscribed patch of alopecia (Govindan & Mandadi, 2021;Hubert et al, 1994).…”

Section: Clinical Presentationmentioning

confidence: 99%

Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Praharaj

Munoli

Udupa

et al. 2021

Human Psychopharmacology

View full text Add to dashboard Cite

Objective: To review the literature on valproate-associated hair abnormalities and the available treatment options. Methods:We searched PubMed and Google Scholar with keywords including "valproate", "valproic acid", "hair", "alopecia", and "effluvium," supplemented with hand search from cross-references. We included all types of studies including case reports in this review. Results: The pathophysiology of hair loss includes telogen effluvium, biotin, mineral deficiency, and possibly hyperandrogenism. Diagnosis is based on history of hair loss or abnormalities following valproate treatment, and is confirmed by use of simple clinical tests such as pull test and modified wash test. Treatment involves reassurance and advice on hair care, and if possible drug discontinuation or dose reduction. Medications such as biotin and other vitamins with minerals supplementation is effective for most individuals with hair loss. Other treatment options are agomelatine, topical valproate or minoxidil, though these lack evidence. Conclusion: Hair abnormalities with valproate are common, benign adverse effects, and management includes general measures and specific treatment options.

show abstract

Anti-epileptic medications

Maroney

Marković²

2022

Side Effects of Drugs Annual

View full text Add to dashboard Cite

Alopecia in Breastfed Infant Possibly Due to Mother Getting Valproate

Cited by 4 publications

References 4 publications

Management of anti-seizure medications in lactating women with epilepsy

Management of anti-seizure medications in lactating women with epilepsy

Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Anti-epileptic medications

Contact Info

Product

Resources

About