Alopecia areata

Strazzulla, Lauren C.; Wang, Eddy Hsi Chun; Avila, Lorena; Sicco, Kristen Lo; Brinster, Nooshin; Christiano, Angela M.; Shapiro, Jerry

doi:10.1016/j.jaad.2017.04.1141

Cited by 321 publications

(112 citation statements)

References 84 publications

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“…It has a reported prevalence in the United States of 0.1% to 0.2%. [167] No studies were found to report the prevalence of SIgAD among individuals with alopecia areata, but four studies have reported the prevalence of alopecia areata within SIgAD populations, varying from 0.9% to 3.51%, with a weighted average of 2.3%. [1,28,40,86] (Table 23) All of these studies were small, with the largest only involving 102 participants.…”

Section: Alopecia Areatamentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

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Section: Alopecia Areatamentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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“…In addition, the prevalence of anti-gliadin antibodies in patients with AA was 18:100 in a study conducted in 2011, being more often in severe variants of AA, in particular alopecia universalis [35]. Furthermore, genome-wide association studies have also revealed shared risk loci between AA and CD [31]. It has been recommended an active search for CD using serological screening tests to diagnose the numerous cases of subclinical CD [9] but a recent study stated that the biological tests to search for CD do not bring information and proof enough, and recommended another approach to disclose gluten intolerance in AA patients [35].…”

Section: Alopecia Areatamentioning

confidence: 99%

“…The main factors affecting prognosis include age at onset and disease extent; younger age at initial presentation and severity at onset are the most important prognostic indicators. The etiology of AA remains unclear, though it is believed to result from a loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle destruction, and the upregulation of inflammatory pathways[31].AA is associated to other autoimmune disorders, such as Addison´s disease, autoimmune thyroiditis, atrophic gastritis, systemic lupus erythematous, rheumatoid arthritis, myasthenia gravis and vitiligo[32]. In 1995, Corazza et al described for the first time the association between AA and CD[39].…”

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confidence: 99%

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Rodrigo¹,

Beteta²,

Álvarez³

et al. 2018

Preprint

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Celiac disease (CD) is an immune-mediated gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, being dermatitis herpetiformis (DH) the best characterized. These associated conditions may be the clue for reaching the diagnosis of CD. Over the last years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in absence of gastrointestinal symptoms, should give rise to an appropriate screening for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated to CD and the possible mechanisms involved.

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“…Alopecia areata (AA) is an inflammatory disease with a genetic and autoimmune basis, leading to various degrees of non-scarring patchy hair loss of the scalp and whole body areas. The estimated prevelance of alopecia areata is between 0.1% and 0.2% [1]. The exact aetiology of AA is still unknown, but genetic disposition has been identified, with some genes like TRAF1/C5 locus.…”

Section: Introductionmentioning

confidence: 99%

Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata

et al. 2020

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Background/aim: Alopecia areata is an inflammatory disease with a genetic and autoimmune basis. We aimed to study the efficacy, and safety of an immunomodulatory therapeutic agent, diphenylcyclopropenone, while manifesting the association with histopathological features, prognostic factors and side effects. Materials and Methods: In this retrospective study, 98 patients (60 men, 38 women) with alopecia who were referred to the "Hair Disease Polyclinic" at Department of Dermatology between 2011 and 2015 were included. Together with medical histories and dermatological examinations, all patients were taken a skin biopsy for histopathological examination prior to the therapy. Therapeutic success was evaluated on the basis of hair re-growth percentage. Results: Regarding the overall treatment success, 33 (34%) patients had complete response, 16 (16%) patients had partial response (between 50-99%), 27 (28%) patients had minimal response (between 1-49%), and 22 (22%) patients were non-responders. Both genders were equally represented in the outcome. Conclusions: There was a significant relation between the severity of alopecia and treatment outcome. (p= 0.038) Patients with alopecia areata had significantly better response when compared to alopecia totalis and universalis. There was no statistically significant relation with other parameters such as disease duration, age, gender, atopy history, age of onset, and histopathological features.

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Alopecia areata

Cited by 321 publications

References 84 publications

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata

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