Alopecia areata

Wasserman, Dan; Guzmán-Sánchez, Daniela; Scott, Kimberly; McMichael, Amy J.

doi:10.1111/j.1365-4632.2007.03193.x

Cited by 215 publications

(211 citation statements)

References 144 publications

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“…The affected skin is usually normal but may be slightly reddened. 2,3 In less than 2% of the cases, the condition can spread to the entire scalp (Alopecia Totalis) or to the entire epidermis (Alopecia Universalis). The exact incidence and prevalence of the disease is not available.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

et al. 2017

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Background: Alopecia areata is a common auto-immune condition, characterized by circumscribed, patches of hair loss usually of the scalp. There are various treatment modalities available but no treatment is fully curative or preventive. Also, alopecia areata can have devastating effects on the patient’s quality of life and self-esteem. The aim of this study was to determine dermoscopy findings of alopecia areata that could be used as a clinical indicator of disease and also to evaluate the efficacy of intralesional injection Triamcinolone acetonide in the treatment of alopecia areata.Methods: Seventy patients with alopecia areata, aged between 11 and 56 years were injected with intralesional triamcinolone acetonide at a 4 weeks interval. Treatment response was evaluated using re-growth scale approach. Dermlite DL3 dermoscope was used to assess disease activity, response to treatment and side effects. Using Wilcoxon signed rank test, changes were assessed in the severity of the disease during follow-ups.Results: Baseline mean percentage area of scalp involved was 23.21±10.70. All the patients had black dots, 98.6% had yellow dots, 27.1% had broken hair, 74.3% had tapering hair and only 71.4% had vellus hair. At baseline, 15 (21.4%) patients had Alopecia Grading Score (AGS) 1, 29 (41.4%) had score 2 and 26 (37.1%) had a score of 3. Injection Triamcinolone acetonide (5 mg/ml) was injected at 1 cm intervals with 0.1 ml on each site and the procedure was repeated every 4 weeks for a maximum period of 24 weeks. From baseline level to the last follow up, proportion of patients with black dots reduced from 100% to 4.3%, yellow dots from 98.6% to 0%, broken hair from 17% to 0% and tapering hair from 74.3% to 0%. Vellus hair increased from 71.4% to 100%. Overall success rate in terms of achievement of re-growth Ssore 4 at last follow up was 60%.Conclusions: Dermoscopic characteristics, such as black dots, yellow dots, broken hair, tapering hair and clustered short vellus hair are primary indicators of alopecia areata.

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Section: Introductionmentioning

confidence: 99%

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

et al. 2017

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“…Ayrıca sakal bölgesi, kaş, kirpikler ve vücudun diğer kıl bulunan bölgeleri ile tırnaklar da etkilenebilir. 4,10 Çalışmamızda klinik olarak AA tanısı konmuş 92 hastanın ilk gelişlerinde alopesik alanlarının dermoskopik incelemeleri yapıldı. Literatürde daha önce de değindiğimiz gibi bu konuda sınırlı sayıda araştırma söz konusudur.…”

Section: Discussionunclassified

“…Tutulumun derecesine, kişinin psişik durumuna göre hastalarda değişik oranda psikopatoloji gözlenmekte ve bu açıdan destek gerekmektedir. 3,4 Dermoskopi (dermatoskopi) dermatolojide primer olarak pigmente lezyonların ve benign-malign deri tümörlerinin tanısında kullanılan, oldukça yararlı bir yöntemdir. 5 Öte yandan saç ve saçlı deri hastalıklarında dermoskopi kullanımı henüz rutin olarak uygulanmamakta olup, bu konuda yapılan çalışmalar kısıtlıdır.…”

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Dermoscopic Findings of Patients with Alopecia Areata

Kayikçi¹,

Arican²

2012

Turkiye Klinikleri J Med Sci

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1064lopesi areata (AA); başta saçlı deri olmak üzere, vücudun herhangi bir yerindeki kıllarda aniden ortaya çıkan, deride görünür herhangi bir inflamasyon olmaksızın keskin sınırlı yuvarlak ya da oval alanlar halinde görülen ve sikatrise yol açmayan kıl dökülmesidir. 1Etiyolojisi kesin olarak bilinmemekte olup, diğer otoimmün hastalıklarla Alopesi Areata Hastalarının Dermoskopik Bulguları Ö ÖZ ZE ET T A Am ma aç ç: : Son dönemlerde saç hastalıklarının incelenmesinde dermoskopi kullanımı giderek önem kazanmaya başlamıştır. Daha önce yapılan çalışmalara göre ırklar arasında saçlı deri dermoskopi bulgularında farklılıklar olabileceği ileri sürülmüştür. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya alopesi areata tanısı konulan 2-65 yaşlarında, 55'i erkek olan 92 hasta katıldı. Hastaların tam bir dermatolojik muayenesi yapıldıktan sonra ilk muayenesindeki dermoskopik bulguları kaydedildi. B Bu ul lg gu ul la ar r: : Çalışmamızda olgularımızın %94,6'sı lokalize alopesiydi. Dermoskopik incelemelerde, sarı nokta %71,7, sivrilmiş saç %71,7, siyah nokta %56,5, kısa vellüs kılları %56,5 ve kırılmış saç %38 oranlarında saptandı. Bunlardan en az birinin görülme olasılığı ise %94,6 olarak bulundu. Kadın-larda sarı nokta (p=0,035) ve sivrilmiş saç (p=0,002) görülme oranları erkeklerden anlamlı düzeyde daha yüksekti. Ayrıca bulgularda; lezyonların lokalizasyonuna, lezyon sayısına ve ilk atak zamanına göre de bazı farklılıklar vardı. S So on nu uç ç: : Çalışmamızla elde ettiğimiz veriler alopesi areata tanısının doğrulanmasında dermoskopik incelemenin yararlı ve tercih edilebilecek bir yöntem olduğunu gös-termektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Alopesi areata; dermoskopi; tanı; saç, kıl A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In the recent years, the use of dermoscopy is becoming more important in the diagnosis of hair diseases. Previous studies suggested that there might be differences among races for the findings of scalp dermoscopy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Ninety two patients of whom 55 were males with alopecia areata aged between 2-65 years were included in the study. After complete dermatological examination, the dermoscopic findings were recorded at their first visit. R Re es su ul lt ts s: : In our study, 94.6% of all cases were localized alopecia areata. On dermoscopy, yellow dots were seen in 71.7%, tapering hairs in 71.7%, black dots in 56.5%, short vellus hairs in 56.5%, and broken hairs in 38% of the patients. The rate of presence of at least one dermascopic finding was 94.6%. The incidences of yellow dots (p=0.035) and tapering hairs (p=0.002) were significantly higher in females compared to males. Moreover, there were some differences according to localization, number and time of onset of the lesions. C Co on nc cl lu us si io on n: : The results of our study show that scalp dermoscopy is a useful and preferable method to confirm the diagnosis of alopecia areata.

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“…1 탈모 (alopecia)는 자가 면역 반응, 호르몬에 의한 모낭의 위축 등 다양한 원인으로 나타나게 된다. 2,3 탈모 치료를 위해 지난 수십 년간 열, 레이저 4,5 등의 물리 적인 치료방법과 미녹시딜, 6,7 Anthralin, 8 cyclosporine A, 9 Lascorbic acid, 10 caffeine 11,12 등의 약물이 개발되어 이용되고 있다. 그 중 미녹시딜은 먹는 발모제인 finasteride와 함께 미 국 FDA 승인을 받은 효능이 검증된 바르는 발모제이다.…”

Section: 서 론unclassified

Characteristics and Hair Growth Efficacy of Water Dissolving Micro-needles Containing Minoxidil Regarding Length of Micro-needles

한미리¹,

김은영²,

정용현³

et al. 2013

Polymer Korea

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Two types of polymeric micro-needles with 250 and 750 µm lengths were prepared by a micromolding process. The geometry of dissolving micro-needles with minoxidil was investigated and the mechanical property of polymer micro-needles was also evaluated. Water dissolving micro-needles containing minoxidil were successfully inserted into skin and delivered minoxidil to the skin layer after 30 min of insertion. The observed hair growth was less when the minoxidil treatment was not applied or used without the micro-needles than that the minoxidil was applied by micro-needles. Histologically, these hair follicles became bigger, and the hair papillae were totally encircled by the hair bulbs. In this feasibility test, we show the successful delivery of minoxidil, and effective treatment of hair loss can be possible by using dissolving micro-needles with minoxidil.Keywords: water dissolving polymer, micro-needle, microstructure, micromolding, hair growth.

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Alopecia areata

Cited by 215 publications

References 144 publications

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

Dermoscopic Findings of Patients with Alopecia Areata

Characteristics and Hair Growth Efficacy of Water Dissolving Micro-needles Containing Minoxidil Regarding Length of Micro-needles

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