Alopecia areata, autoimmunity, and Down's syndrome.

Vivier, Anthony du; Munro, D.D.

doi:10.1136/bmj.1.5951.191

Cited by 116 publications

(54 citation statements)

References 15 publications

(7 reference statements)

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“…Regarding the subtypes of alopecia areata, according to the classification of Ikeda [17], 2 patients showed the atopic type and the remaining 4 the common type, associated in 2 of them with ophiasis. Alopecia has been reported to be associated with autoimmune diseases such as thyroiditis [18], vitiligo [19]and – in single reports – with hypothyroidism [20]and trachyonychia in people with DS [21]. Alopecia was associated in 2 patients of our sample with noncongenital hypothyroidism.…”

Section: Discussionmentioning

confidence: 66%

An Updated Survey on Skin Conditions in Down Syndrome

et al. 2002

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Background: Only three not concordant surveys have been published on skin conditions associated with Down syndrome. Objective: A sample ranging from infancy to adulthood, using acknowledged criteria for diagnosis, may highlight the skin involvement in Down syndrome. Methods: We report the skin conditions observed in 203 people with Down syndrome, separated according to five different age ranges. We have set up two main groups of skin features: the phenotype and the dermatological diseases. Results: The single palmar crease and xerosis are strongly represented within the phenotype. Among the dermatological diseases, folliculitis and syringomas have been observed mainly in adolescence and adulthood. Atopic dermatitis has been recognized in 10 subjects. Alopecia areata and milia-like idiopathic calcinosis cutis appeared in 6 subjects. Conclusion: People with Down syndrome suffer from peculiar dermatoses (syringomas, milia-like calcinosis, elastosis perforans serpiginosa). Other conditions (folliculitis, alopecia areata) are frequently observed.

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Section: Discussionmentioning

confidence: 66%

An Updated Survey on Skin Conditions in Down Syndrome

et al. 2002

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“…It remains uncertain whether this arthropathy repreor a separate illness occurring as a result of the known genetic and immunologic abnormalities in Down's syndrome (2). Previously described abnormalities in Down's syndrome include chronic active hepatitis and multiple serologic abnormalities (3), psoriatic arthritis (4), gouty arthritis (9, an increased incidence of thyroid antibodies (6), and an increased incidence of alopecia areata (7). We recently treated a patient with Down's syndrome who developed an inflammatory polyarthritis with additional clinical and serologic features of SLE.…”

Section: To the Editormentioning

confidence: 99%

Systemic lupus erythematosus and Down's syndrome

Torretti

1985

Arthritis & Rheumatism

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“…Immunodeficiency with hypogammaglobulinemia [Becker and Buckley, 1977] and especially autoimmune diseases are quite often reported to be asso ciated with AA. Examples of such autoim mune diseases are thyroid disease [Muller and Winkelmann, 1963], autoimmune he molytic anemia [Becker and Buckley, 1977], autoimmune polyendocrine disease [Bottazzo et al, 1974] and vitiligo [Cunliffe et al, 1968], Autoantibodies in AA patients have been reported against: thyroid antigen [Du Vivier and Munro, 1975], smooth mus cle [Main et al, 1975], gastric parietal cells [Kern et al, 1973], adrenal cells [Kern et al, 1973] and endothelial cells [Cormane, 1979]. It must, however, be emphasized that antifollicle autoantibodies have never been demonstrated [Klaber and Munro, 1978;Kern et al, 1973].…”

Section: Introductionmentioning

confidence: 99%

“…It must, however, be emphasized that antifollicle autoantibodies have never been demonstrated [Klaber and Munro, 1978;Kern et al, 1973]. Finally, it should be mentioned that Down's disease (trisomy 21) may be associated with A A [Du Vivier and Munro, 1975].…”

Section: Introductionmentioning

confidence: 99%

T Cell Subpopulations and Their Functions in vitro

Ros

Stedingk

et al. 1981

Int Arch Allergy Immunol

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T lymphocyte subpopulations and their in vitro activities were determined in patients with alopecia areata (AA) and alopecia universalis (AU). The frequencies of T cells with receptors for IgG and T cells with receptors for IgM were determined in 16 cases. The IgG and IgM production of B lymphocytes cocultured with autologous and allogeneic T lymphocytes in the presence of PWM was determined in 12 and 9 cases, respectively, and the antibody-dependent cell-mediated cytotoxicity (ADCC) of unfractionated lymphocytes was examined in 6 cases. Patients with AA and AU had a higher proportion of Tg cells and more pronounced ADCC of unfractionated peripheral lymphocytes than normal persons. Furthermore, PWM-induced Ig production of B lymphocytes in the presence of autologous T lymphocytes seemed to be lower than that of controls.

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Alopecia areata, autoimmunity, and Down's syndrome.

Cited by 116 publications

References 15 publications

An Updated Survey on Skin Conditions in Down Syndrome

An Updated Survey on Skin Conditions in Down Syndrome

Systemic lupus erythematosus and Down's syndrome

T Cell Subpopulations and Their Functions in vitro

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