Alopecia areata and narcolepsy: a tale of obscure autoimmunity

Nigam, Gaurav; Pathak, Charu; Riaz, Muhammad Bilal

doi:10.1136/bcr-2015-211523

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…In one study, an association was found between alopecia areata and narcolepsy 31 . One case was reported of an association between type 1 narcolepsy and atopic dermatitis 47 . In addition, people with cutaneous morbidities may be difficult to treat because of the altered sleep‐wake cycle.…”

Section: Resultsmentioning

confidence: 99%

Sleep disorders in dermatology – a comprehensive review

Mann

Gorai

Staubach‐Renz

et al. 2023

J Deutsche Derma Gesell

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Summary Sleep is a normal physiological process that accounts for approximately one third of a person's life. Disruption of the normal sleep cycle, which maintains physiological homeostasis, can lead to pathology. It is not known whether sleep disturbance causes skin disease or skin disease causes sleep impairment, but a bidirectional influence is suspected. We have compiled the data from published articles on “sleep disorders in dermatology” in PubMed Central from July 2010 to July 2022 (with the option “full text available”) and provide an overview of sleep disorders associated with dermatological conditions and certain drugs used in dermatology as well as sleep disturbances for which some drugs used can cause itch or dermatological issues. Atopic dermatitis, eczema and psoriasis have been shown to be exacerbated by sleep problems and vice versa. Sleep deprivation, night‐time pruritus and disrupted sleep cycles are often used to assess treatment response and quality of life in these conditions. Some medications used primarily for dermatological conditions have also been associated with alterations in the sleep‐wake cycle. Addressing patients sleep disorders should be an integral part of the management of dermatological conditions. More studies are needed to further investigate the influence of sleep and skin disorders.

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Section: Resultsmentioning

confidence: 99%

Sleep disorders in dermatology – a comprehensive review

Mann

Gorai

Staubach‐Renz

et al. 2023

J Deutsche Derma Gesell

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“…The association of NT1 and alopecia areata -an autoimmune dermatological disorder -was described in 1992, although new case reports have been presented and the autoimmune association has not been established definitively [34,35].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases

Martínez-Orozco¹,

Fernández‐Arquero²,

Vicário³

et al. 2022

J Clin Med Res

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Background:The aim of this study was to evaluate the long-term outcome of our series of narcolepsy type 1 (NT1) patients with comorbid autoimmune diseases (ADs) and other immunopathological diseases (IDs), focusing on the incidence of new ADs and IDs in this sample.Methods: A longitudinal observational study was conducted over 6 years (2014 -2020) in a series of 158 Caucasians NT1 patients (96 males; mean age: 50.1 ± 19.0 years) from the previous study. All but one case (familial case) were HLA-DQB1*06:02-positive. The diagnosis of narcolepsy was made according to the International Classification of Sleep Disorders (ICSD-3).Results: Twenty-one patients have been diagnosed with a new ID, 10 of them with an AD (autoimmune thyroid disease, psoriasis, rheumatoid arthritis, transverse myelitis, granuloma annulare, primary biliary cirrhosis, alopecia areata and antiphospholipid syndrome), and 11 with other IDs (allergic rhinitis, allergic asthma, atopic dermatitis, food allergy, contact dermatitis and drug allergy). One patient was diagnosed with two new ADs. We found IDs in 46 patients (24 females and 22 males) and the overall prevalence in this series is actually 29.11%; 22 of them (13.92%) had an AD, with a percentage higher than estimated in the general population. Conclusions:The prevalence of AD/ID is high in our series, suggest-ing that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.

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“…In einer Studie wurde eine Assoziation zwischen Alopecia areata und Narkolepsie festgestellt 31 . Es wurde ein Fall einer Assoziation zwischen Narkolepsie Typ 1 und AD beschrieben 47 . Außerdem ist die Behandlung von Menschen mit kutaner Morbidität aufgrund des veränderten Schlaf‐Wach‐Zyklus möglicherweise erschwert.…”

Section: Ergebnisse Und Diskussionunclassified

Schlafstörungen in der Dermatologie – eine umfassende Übersicht

Mann¹,

Gorai

Staubach‐Renz³

et al. 2023

J Deutsche Derma Gesell

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ZusammenfassungSchlaf ist ein normaler physiologischer Prozess, der etwa ein Drittel des Lebens eines Menschen ausmacht. Da der normale Schlafzyklus die physiologische Homöostase aufrechterhält, kann seine Störung zu Erkrankungen führen. Es ist zwar nicht bekannt, ob Schlafstörungen Hautkrankheiten verursachen oder Hautkrankheiten den Schlaf beeinträchtigen, es besteht jedoch der Verdacht auf einen bidirektionalen Einfluss. Wir haben Daten zu „Schlafstörungen in der Dermatologie“ zusammengetragen, die von Juli 2010 bis Juli 2022 in PubMed Central veröffentlicht wurden (mit der Option „Volltext verfügbar“) und geben einen Überblick zu Schlafstörungen im Zusammenhang mit dermatologischen Erkrankungen und bestimmten Medikamenten, die in der Dermatologie verwendet werden, sowie zu Schlafstörungen, bei denen einige eingesetzte Medikamente Juckreiz oder dermatologische Probleme verursachen können. Es ist bekannt, dass atopische Dermatitis, Ekzeme und Psoriasis durch Schlafprobleme verschlimmert werden und umgekehrt. Bei diesen Erkrankungen werden Schlafmangel, nächtlicher Pruritus und gestörte Schlafzyklen oft zur Beurteilung des Behandlungserfolgs und der Lebensqualität eingesetzt. Zudem wurden einige Medikamente, die in erster Linie für dermatologische Erkrankungen verwendet werden, mit Veränderungen des Schlaf‐Wach‐Zyklus in Zusammenhang gebracht. Die Bewältigung der Schlafstörungen von Patienten sollte einen integralen Bestandteil des Managements dermatologischer Erkrankungen darstellen. Weitere Studien sind erforderlich, um den Einfluss von Schlaf und Hauterkrankungen weiter zu untersuchen.

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Alopecia areata and narcolepsy: a tale of obscure autoimmunity

Cited by 4 publications

References 7 publications

Sleep disorders in dermatology – a comprehensive review

Sleep disorders in dermatology – a comprehensive review

Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases

Schlafstörungen in der Dermatologie – eine umfassende Übersicht

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