Alopecia areata

Strazzulla, Lauren C.; Wang, Eddy Hsi Chun; Avila, Lorena; Sicco, Kristen Lo; Brinster, Nooshin; Christiano, Angela M.; Shapiro, Jerry

doi:10.1016/j.jaad.2017.04.1142

Cited by 183 publications

(84 citation statements)

References 58 publications

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“…In the literature, there is no specific treatment for BAA. It is recommended to determine the treatment protocol according to the age of the patient and severity of the disease (18). In our trial, comorbidities and laboratory results are similar to those in the literature (3,4,10,11).…”

Section: Discussionsupporting

confidence: 78%

The usefulness of dermoscopic findings in the clinical evaluation of bread alopecia areata

Köse¹

2019

Erciyes Med J

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The aim of this study is to investigate the usefulness of dermoscopic findings in the clinical evaluation of beard alopecia areata (BAA). Materials and Methods: A total of 38 patients who presented with BAA diagnosed via clinical evaluation and 38 adults who did not have BAA (control group) were included. Their age, skin phototype, localization, severity, scalp involvement, duration of the disease, laboratory findings, and concomitant disorders were noted. Clinical and dermoscopic photos were taken by videodermoscope and recorded. Dermoscopic findings were analyzed according to the checklist described in previous articles for scalp alopecia. Results: Clinical severity of alopecia areata was observed as 13 (34.2%) solitary lesions, 22 (57.9%) multiple lesions, and 3 (11.1%) cases of total beard loss. According to the follicular features, white vellus and tapering hairs were detected 26 (68.4%) and 8 (21.1%) in the patient group, respectively. The difference between white vellus (p=0.001) and tapering hairs (p=0.003) was significant between the patient and the control groups. Other follicular findings, such as yellow dots, black dots, black vellus hairs, broken hairs, hair diameter diversity, and gray-white dots, did not show a significant difference between the patient and control groups. None of the interfollicular findings were significantly different between the two groups. Conclusion: According to our study, a dermoscopic evaluation is useful in the clinical evaluation of BAA. Detection of the white vellus and tapering hairs may guide diagnosing of BAA.

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Section: Discussionsupporting

confidence: 78%

The usefulness of dermoscopic findings in the clinical evaluation of bread alopecia areata

Köse¹

2019

Erciyes Med J

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“…2,3 The preferred treatments for AA include therapeutic agents, such as topical or intralesional corticosteroid, and contact immunotherapy. 4,5 Other treatments, including systemic corticosteroids, anthralin, excimer laser, and novel therapeutics, such as Janus kinase inhibitors, have also been used. Despite the numerous treatment options, the overall prognosis of AA is not favorable, involving relapse and recalcitrant progression.…”

mentioning

confidence: 99%

Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata

et al. 2018

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IMPORTANCE Contact immunotherapy with diphenylcyclopropenone or squaric acid dibutyl ester is a preferred treatment for severe alopecia areata; however, the defined criteria for therapeutic hair regrowth and regrowth rate have been highly heterogeneous across studies. OBJECTIVE To summarize the clinical outcomes of contact immunotherapy for alopecia areata according to standardized criteria for therapeutic hair regrowth and several prognostic factors.

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“…Genome-wide association studies (GWASs) have greatly facilitated our understanding of the immune pathways involved in AA. Some genes found in AA patients were related to autophagy/apoptosis, regulatory T-cells (T regs) and Janus kinase signaling [15].…”

Section: Discussionmentioning

confidence: 99%

“…Oral Janus kinase inhibitors (tofacitinib, ruxolitinib, baricitinib) are being popularly investigated as potential treatment for AA in recent years. The response rate revealed in one meta-analysis was impressive (72.4%), with mean time to initial and complete hair growth about 2.2 and 6.7 months [8,15,16]. Various response rates of phototherapy for treatment of AA, including narrow-band ultraviolet (UV) B [17,18], topical psorlaen-UVA [19,20], and UVA-1 [21], have been reported.…”

Section: Introductionmentioning

confidence: 99%

Alopecia Totalis Treated with 1064 nm Picosecond Nd:YAG Laser: A Case Report

Juang

Tsai²,

Wang

et al. 2019

Applied Sciences

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Alopecia areata (AA) is an autoimmune disorder causing nonscarring hair loss. Alopecia totalis (AT), the severe form of AA, is usually refractory to many first-line treatments including topical and intralesional corticosteroids and topical immunotherapy. Systemic corticosteroids, ultraviolet light phototherapy, and immunosuppressants may be effective but can cause side effects and high recurrence rates after discontinuing treatment. Janus kinase inhibitors and numerous types of lasers, such as 308 nm excimer laser or light, low-level laser therapy, and fractional lasers have been explored for alternative treatment of AA over the past few years with beneficial effects. Herein, we presented a case of AT treated with the novel 1064 nm picosecond Nd:YAG laser (ps-Nd:YAG) (Cutera, Brisbane, CA, USA) under a split-scalp study. A 25-year-old woman presenting with AT for two years was treated with topical and intralesional steroid and the 1064 nm Nd-YAG picosecond laser on the right half of the scalp. The laser treatment interval was once a month. The left half of the scalp was treated with topical and intralesional steroids alone. After treatment for six times, the right half of the scalp had greater improvement than the left half of the scalp. 1064 nm picosecond Nd:YAG laser therapy may be an effective alternative adjuvant treatment for AT.

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Alopecia areata

Cited by 183 publications

References 58 publications

The usefulness of dermoscopic findings in the clinical evaluation of bread alopecia areata

The usefulness of dermoscopic findings in the clinical evaluation of bread alopecia areata

Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata

Alopecia Totalis Treated with 1064 nm Picosecond Nd:YAG Laser: A Case Report

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