Aloin protects mice from diet-induced non-alcoholic steatohepatitis <i>via</i> activation of Nrf2/HO-1 signaling

Xu, Qiushi; Fan, Yunhui; Loor, Juan J.; Liang, Yusheng; Lv, Hongming; Sun, Xudong; Jia, Haiyang; Xu, Chuang

doi:10.1039/d0fo02684k

Cited by 18 publications

(14 citation statements)

References 43 publications

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“…However, searching for effective treatment drugs for IDD is still a huge challenge. Aloin, extracted from aloe plants, has been shown to have anti-inflammatory, antioxidant, and bone protective activities, but its effects on IDD have not been confirmed [ 37 , 38 , 40 ]. In our study, we demonstrated that aloin treatment can reverse TNF- α -induced extracellular matrix metabolism disorder, apoptosis, oxidative stress, and the production of proinflammatory factors in NPCs through the TAK1/NF- κ B/NLRP3 pathway.…”

Section: Discussionmentioning

confidence: 99%

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Chen

Qiu

et al. 2022

Stem Cells International

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Intervertebral disc degeneration (IDD) is a degenerative disease that is characterized by decreased matrix synthesis and extra degradation, nucleus pulposus cells (NPCs) apoptosis, and infiltration of inflammatory factors. Aloin, a colored compound from aloe plants, has been shown to be effective against skeletal degenerative diseases, but it is unclear whether it is protective against IDD. Herein, we investigated the role of aloin in NPCs. In our study, the upregulation of proinflammatory factors, apoptosis, and unbalanced matrix metabolism were observed in degenerative NP tissues. We found that aloin had a curative effect on extracellular matrix metabolism and apoptosis in TNF-alpha- (TNF-α-) treated NPCs by inhibiting oxidative stress and the proinflammatory factor expression. Further investigation revealed that aloin treatment suppressed the TAK1/NF-κB pathway. Moreover, the expression level of the NLPR3 inflammasome was downregulated after aloin treatment in TNF-α-treated NPCs. In summary, our results demonstrated that aloin treatment can reverse TNF-α-induced unbalanced matrix metabolism and apoptosis of NPCs via the TAK1/NF-κB/NLRP3 axis. This study supports that aloin can be a promising therapeutic agent for IDD.

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Section: Discussionmentioning

confidence: 99%

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Chen

Qiu

et al. 2022

Stem Cells International

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“…Aloin, also known as barbaloin, is a natural aloe- derived anthraquinone compound that can ameliorate oxidative stress, anti-apoptosis and anti-inflammation on liver diseases ( 114 , 115 ). A recent study also revealed that aloin can enhance antioxidant, anti-inflammatory and anti-apoptotic activity by activating Nrf2/HO-1 signaling in Nrf2 KO (Nrf2−/−) C57BL/6 mice model fed CDAAH diet models ( 116 ). Moreover, aloin could reduce oxidative stress, liver inflammation in rats fed HFHFD ( 18 ).…”

Section: Herbs and Active Tcm Ingredientsmentioning

confidence: 99%

Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine

Zhou

Zhang²,

Li³

et al. 2022

Front. Endocrinol.

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Non-alcoholic fatty liver disease (NAFLD) is a global health problem, and its prevalence has been on the rise in recent years. Traditional Chinese Medicine (TCM) contains a wealth of therapeutic resources and has been in use for thousands of years regarding the prevention of liver disease and has been shown to be effective in the treatment of NAFLD in China. but the molecular mechanisms behind it have not been elucidated. In this article, we have updated and summarized the research and evidence concerning herbs and their active ingredients for the treatment in vivo and vitro models of NAFLD or NASH, by searching PubMed, Web of Science and SciFinder databases. In particular, we have found that most of the herbs and active ingredients reported so far have the effect of clearing heat and dispelling dampness, which is consistent with the concept of dampness-heat syndrome, in TCM theory. we have attempted to establish the TCM theory and modern pharmacological mechanisms links between herbs and monomers according to their TCM efficacy, experiment models, targets of modulation and amelioration of NAFLD pathology. Thus, we provide ideas and perspectives for further exploration of the pathogenesis of NAFLD and herbal therapy, helping to further the scientific connotation of TCM theories and promote the modernization of TCM.

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“…Moreover, a research suggested that Aloe vera extract may hold promise in the treatment of ulcerative colitis by enhancing colon mucus secretion . In addition, aloin also protected mice from diet-induced nonalcoholic steatohepatitis . Another important property of aloin is its anticancer effect, which has been demonstrated in various animal models of cancer, such as colorectal, liver, and gastric cancers. − However, as far as we know, the use of aloin has not been reported in liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Aloin Attenuates Oxidative Stress, Inflammation, and CCl₄-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling

Bai,

Qian,

Cai

et al. 2023

J. Agric. Food Chem.

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Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling

Abstract: Aloin, a naturally occurring anthraquinone glycoside derived from the Aloe species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown.

Cited by 18 publications

References 43 publications

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine

Aloin Attenuates Oxidative Stress, Inflammation, and CCl₄-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling

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Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling

Abstract: Aloin, a naturally occurring anthraquinone glycoside derived from the Aloe species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown.

Cited by 18 publications

References 43 publications

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway

Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine

Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling

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Aloin Attenuates Oxidative Stress, Inflammation, and CCl₄-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling