Aloin delivery on buccal mucosa:ex vivostudies and design of a new locoregional dosing system

Abstract

Following application of matrix tablets on porcine buccal mucosa, the amount of discharged drug recovered in the tissue should be sufficient to produce the desired effects, providing therapeutic drug levels directly at the site of action. Aloin-loaded tablets are valid candidates for prevention/treatment of potentially malignant disorders and oral cancer and could potentially lead to clinically relevant drug delivery system as coadjuvant of conventional chemotherapy/radiation therapy.

Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailability

“…Drug release in buffer solution simulating saliva was assessed using the flow through system previously described [ 32 ]. Briefly, the system consists of a container for the buffer solution simulating saliva (100 mL) from which the liquid is forced into a Plexiglass release chamber.…”

Enhanced In Situ Availability of Aphanizomenon Flos-Aquae Constituents Entrapped in Buccal Films for the Treatment of Oxidative Stress-Related Oral Diseases: Biomechanical Characterization and In Vitro/Ex Vivo Evaluation

“…Film dissolution in buffer solution simulating saliva was assessed using the flow through the system previously described [39]. Briefly, the system consists of beker containing a buffer solution simulating saliva (100 mL) thermostatted at 37 °C from which the liquid is forced to a Plexiglass release chamber by a peristaltic pump (Bio-Rad Econo Pump, Hercules, CA, USA).…”

“…Considering the beneficial anti-oxidative effects of AFA, this compound could be suitable for the treatment of the oral diseases related to OS. This hypothesis leads us to the realization of a topical delivery system of AFA to apply on buccal mucosa since it provides an excellent opportunity to deliver actives for the loco-regional treatment of oral lesions and pathologies [39].…”

Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation

“…The mucoadhesive force (dyne/cm 2 ) was determined using the minimal weight that caused detachment of the mucosal tissue from the tablet surface. $\text{Mucoadhesive force}false(\text{dyne}/{\text{cm}}^{2}false)=\frac{mg}{A}$where m = weight in grams required for detachment, g = acceleration due to gravity (980 cm/s2) and A = area of mucosal surface exposed that equals the tablet area 22…”