Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies

Deora, Neha; Venkatraman, Krishnan

doi:10.1016/j.jaim.2022.100675

Cited by 16 publications

(15 citation statements)

References 83 publications

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“…The results showed that blood sugar levels in each group of mice experienced changes (Cai et al, 2023). Some experienced a decrease, and some even experienced an increase even though they had been given treatment to reduce blood sugar levels (Deora & Venkatraman, 2022). In the positive control, four mice experienced an increase when their blood sugar levels were tested on the seventh day.…”

Section: Resultsmentioning

confidence: 99%

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Ardiantya Sudarsono,

Wibowo,

Sugiyanto

et al. 2023

ihj

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The research aims to know the effectiveness of grape seeds in lowering blood sugar levels in white rats. The research began with grape seed extraction using the maceration method. The results of macerate were given to white rats that were given grape seed extract samples at doses of 75 mg/200 grams BW, 125 mg/200 grams BW, and 250 mg/200 grams BW. The positive control was metformin, and the negative control was given distilled water. All were given treatment for 14 days. On days seven and 14, a blood sugar test was carried out to assess the effectiveness of grape seed extract. The results showed that of the five treatment groups, sample group I (extract at a dose of 75 mg/200 gram BW) and sample group III (extract at a dose of 250 mg/200 gram BW) affected reducing blood sugar levels in rats. This is proven by comparing blood sugar levels after being given alloxan on the seventh day in the two groups, showing better results in reducing blood sugar levels than the other groups. It can be concluded that grape seed extract can properly reduce blood sugar levels in white rats with type II diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Ardiantya Sudarsono,

Wibowo,

Sugiyanto

et al. 2023

ihj

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“…There aren't many studies on Aloe Vera's capacity to treat diabetic dyslipidemia, though. She concentrated on the potential role of Aloe vera and its active ingredients in treating diabetic dyslipidemia as well as their mechanisms of action in pre-clinical and clinical investigations in this systematic review [ 16 ]. According to a study by Bunyapraphatsara, numerous alternative therapies are highly helpful in the treatment of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Effect of aloe vera juice on type 2 diabetes mellitus among Indian patients

Prakash

2023

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It is of interest to assess the effect of Aloe vera juice on type 2 diabetes mellitus. Non-probability convenience sampling techniques was used to obtain sample of fifty type 2 diabetic patients who satisfied the inclusion criteria. Blood sugar level was assessed by using glucometer before and after consumption of Aloe vera juice. The average post-test score in the experimental group 177.43 (Standard deviation 17.64) was significantly lower than the average post-test score in control group 128.76 (Standard deviation 27.50). Unpaired ‘t’ value 7.2926. It shows there is a significant difference found in the post-test scores on the level of blood glucose. Chi square analysis showed that there was no correlation between patients with demographic variables except age, occupation, smoking habit, habit of alcoholism and family history.

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“…Aloe vera has a variety of pharmacological effects and has been found to lower blood glucose and blood lipids, which is associated with many of its active ingredients. For example, the polysaccharide component can regulate glucose metabolism by activating gluconeogenesis and inhibiting gluconeogenesis, and phytosterols can reduce serum-free fatty acids and triglyceride levels and improve glucose homeostasis and lipid metabolism [ 115 ]. Huseini et al administered 300 mg of Aloe vera gel capsules (AC) orally every 12 h to 35 patients with type 2 diabetes to assess the effectiveness of Aloe vera gel in lowering blood sugar.…”

Section: Advances In the Clinical Application Of Acmentioning

confidence: 99%

A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application

et al. 2023

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Aloe vera is a kind of herb rich in polysaccharides. Acemannan (AC) is considered to be a natural polysaccharide with good biodegradability and biocompatibility extracted from Aloe vera and has a wide range of applications in the biomedical field due to excellent immunomodulatory, antiviral, antitumor, and tissue regeneration effects. In recent years, clinical case reports on the application of AC as a novel biomedical material in tissue regenerative medicine have emerged; it is mainly used in bone tissue engineering, pulp–dentin complex regeneration engineering, and soft tissue repair, among other operations. In addition, multiple studies have proved that the new composite products formed by the combination of AC and other compounds have excellent biological and physical properties and have broader research prospects. This paper introduces the preparation process, surface structure, and application forms of AC; summarizes the influence of acetyl functional group content in AC on its functions; and provides a detailed review of the functional properties, laboratory studies, clinical cutting-edge applications, and combined applications of AC. Finally, the current application status of AC from basic research to clinical treatment is analyzed and its prospects are discussed.

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Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies

Cited by 16 publications

References 83 publications

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Test the Effectiveness of Grape Seed Extract as an Antidiabetic Drug In Male White Rats Wistar Strain

Effect of aloe vera juice on type 2 diabetes mellitus among Indian patients

A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application

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