Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats

Tabatabaei, Seyed Reza Fatemi; Ghaderi, Shahab; Bahrami-Tapehebur, Mohammad; Farbood, Yaghoob; Rashno, Masome

doi:10.1016/j.biopha.2017.09.146

Cited by 56 publications

(28 citation statements)

References 66 publications

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“…It was revealed that ascorbic acid treatment reduced the depressive behavior in STZ-nicotinamide-induced diabetic rats [55]. Also, it was demonstrated that ascorbic acid reduced oxidative stress, hyperglycemia, and inflammation [55, 56]; on the other hand, positive results with Aloe vera treatment were found, which has antioxidative, neuroprotective, and antidiabetic effects. The study revealed that Aloe vera displayed antidepressant effects in STZ-induced diabetic rats, and these effects were suggested to be related to hypoglycemic and antioxidant properties of Aloe vera in the hippocampus [56].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Réus

Carlessi

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

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Both conditions, major depressive disorder (MDD) and diabetes mellitus (DM) are chronic and disabling diseases that affect a very significant percentage of the world’s population. Studies have been shown that patients with DM are more susceptible to develop depression, when compared to the general population. The opposite also happens; MDD could be a risk factor for DM development. Some mechanisms have been proposed to explain the pathophysiological mechanisms involved with these conditions, such as excess of glucocorticoids, hyperglycemia, insulin resistance, and inflammation. These processes can lead to an increase in damage to biomolecules and a decrease in antioxidant defense capacity, leading to oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Réus

Carlessi

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…These studies indicate that independent of ER stress, IRE1α exerts its proapoptotic effect by activating the ASK1-JNK1/2 pathway, supporting the hypothesis that IRE1α activity and ASK1 pathway activation has a reciprocal causal relationship during DICD. Additionally, diabetes-induced oxidative stress in the hippocampus of rats has been previously reported as a factor that contributes to cognitive dysfunction (Wang et al, 2010;Tabatabaei et al, 2017;Farbood et al, 2019) with evidence of synaptic damage (Fukui et al, 2001(Fukui et al, , 2002 and excessive neuronal apoptosis (Farbood et al, 2019;Nazarnezhad et al, 2019;Yan et al, 2019). The ASK1-JNK1/2 pathway, the important downstream of oxidative stress, may be the major mechanism for oxidative stress-mediated apoptosis during DICD, suggesting that cellular stress does not independently affect DICD development.…”

Section: Discussionmentioning

confidence: 99%

The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline

Yuan

et al. 2020

Front. Cell Dev. Biol.

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Diabetes significantly induces cognitive dysfunction. Neuronal apoptosis is the main cause of diabetes-induced cognitive decline (DICD). Apoptosis signal-regulating kinase 1 (ASK1) and endoplasmic reticulum (ER) stress are remarkably activated by diabetes. The role and relationship of ASK1-JNK1/2 signaling and ER stress in DICD have not yet been elucidated. In this study, we used db/db mice as the DICD animal model and confirmed that db/db mice displayed cognitive decline with inferior learning and memory function. Diabetes significantly induced morphological and structural changes, excessive neuronal apoptosis, Aβ 1−42 large deposition, and synaptic dysfunction in the hippocampus. Mechanistic studies found that diabetes significantly triggered ASK1-JNK1/2 signaling activation and increased ER stress in the hippocampus. Moreover, diabetes enhanced the formation of the IRE1α-TRAF2-ASK1 complex, which promotes the crosstalk of ER stress and the ASK1-JNK1/2 pathway during DICD. Furthermore, 4-PBA treatment blocked high glucose (HG)-induced ASK1-JNK1/2 signaling activation, and excessive apoptosis in vitro. Inhibiting ASK1 via siRNA remarkably ameliorated the HG-induced increase in p-IRE1α and associated apoptosis in SH-SY5Y cells, suggesting that ASK1 is essential for the assembly and function of the proapoptotic kinase activity of the IRE1α signalosome. In summary, ER stress and ASK1-JNK1/2 signaling play causal roles in DICD development, which has crosstalk through the formation of the IRE1α-TRAF2-ASK1 complex.

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“…Aloe species are widely used CAM plants, with records dating back to Sumerian clay tablets from 2100 BC, and extensive use by ancient Egyptian, Arab, Greek, Roman, and Indian cultures (Sánchez-Machado et al , 2017). Today, the extracted tissues are processed for treatment of radiation (burn) injuries (Rao et al , 2017; Silva et al , 2014), gastrointestinal issues (Xu et al , 2016; Boudreau et al , 2017), inflammation (Vázquez et al , 1996), wounds (Choi et al , 2001), diabetes (Bunyapraphatsara et al , 1996; Tabatabaei et al , 2017), and mitigation of immune system weakening associated with HIV–AIDs (Olatunya et al , 2012), and it even has antitumorigenic properties (Hussain et al , 2015; Shalabi et al , 2015). Aloe spp.…”

Section: Cam Species With Agricultural Valuementioning

confidence: 99%

Undervalued potential of crassulacean acid metabolism for current and future agricultural production

Davis

Simpson²,

Gil-Vega³

et al. 2019

Journal of Experimental Botany

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Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats

Cited by 56 publications

References 66 publications

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder

The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline

Undervalued potential of crassulacean acid metabolism for current and future agricultural production

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