Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats

A primer on common supplements and dietary measures used by patients with inflammatory bowel disease

“…Aloe vera has been shown to reduce intestinal inflammation in murine studies. [42][43][44] A small RCT of 44 patients found 47% to have a clinical response after 4 weeks of aloe vera gel supplemental use compared with 14% on placebo in mildto-moderate UC, defined as Simple Clinical Colitis Activity Index (SCCAI) ⩾ 3. 45 However, no significant difference was found in sigmoidoscopic improvement (p = 0.65).…”

Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment

“…[15][16][17][18][19][20] In particular, aloe has attracted attention as a potential UC therapeutic in clinical as well as preclinical studies owing to its anti-inflammatory effects, which decrease TNF-α, IL-1β, IL-2, and IL-8, and increase IL-10, but also its components including vitamins A, E, C, and selenium to potentially exert anti-oxidant properties. [21][22][23][24][25][26][27][28][29][30][31][32][33] Accordingly, consistent efforts have been made to develop a formulation to realize the potential of this natural product, aloe, for the treatment of UC. [26][27][28][29] Plant-derived vesicles (PDVs) are nano-sized extracellular vesicles (30-300 nm) that are naturally released from plants and carry a variety of cargo, including proteins, lipids, and nucleic acids, as a means of intercellular communication.…”

“…15–20 In particular, aloe has attracted attention as a potential UC therapeutic in clinical as well as preclinical studies owing to its anti-inflammatory effects, which decrease TNF-α, IL-1β, IL-2, and IL-8, and increase IL-10, but also its components including vitamins A, E, C, and selenium to potentially exert anti-oxidant properties. 21–33 Accordingly, consistent efforts have been made to develop a formulation to realize the potential of this natural product, aloe, for the treatment of UC. 26–29…”