Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug

Sun, Zhonghua; Yu, Cuilian; Wang, Wei; Guo, Yu; Zhang, Tingting; Zhang, Lin; Zhang, Jiguo; Wei, Kai

doi:10.3389/fmicb.2018.02338

Cited by 48 publications

(29 citation statements)

References 40 publications

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“…In silico analysis also revealed that terpene Ginkgolide A can strongly inhibit SARS CoV-2 protease enzyme ( 284 ). Carbohydrates, mainly classified as monosaccharides, disaccharides, polysaccharides, and oligosaccharides ( 282 ), are found as antiviral agent against Human rotavirus, Influenza A virus, HSV-1, HSV-2, Herpes simplex virus (HSV), RSV, Coxsackie B3 Virus, and VSV [( 285 ); Table 4 ]. Acyclovir is an FDA (Food and Drug Administration) approved antiviral drug which is obtained from Carissa edulis ( Supplementary Table 1 ).…”

Section: Plant-based Antiviral Compounds: Group Basis Mechanism Of Acmentioning

confidence: 99%

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

et al. 2020

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COVID-19, a disease induced by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), has been the cause of a worldwide pandemic. Though extensive research works have been reported in recent days on the development of effective therapeutics against this global health crisis, there is still no approved therapy against SARS-CoV-2. In the present study, plant-synthesized secondary metabolites (PSMs) have been prioritized to make a review focusing on the efficacy of plant-originated therapeutics for the treatment of COVID-19. Plant metabolites are a source of countless medicinal compounds, while the diversity of multidimensional chemical structures has made them superior to treat serious diseases. Some have already been reported as promising alternative medicines and lead compounds for drug repurposing and discovery. The versatility of secondary metabolites may provide novel antibiotics to tackle MDR (Multi-Drug Resistant) microbes too. This review attempted to find out plant metabolites that have the therapeutic potential to treat a wide range of viral pathogens. The study includes the search of remedies belonging to plant families, susceptible viral candidates, antiviral assays, and the mode of therapeutic action; this attempt resulted in the collection of an enormous number of natural therapeutics that might be suggested for the treatment of COVID-19. About 219 plants from 83 families were found to have antiviral activity. Among them, 149 plants from 71 families were screened for the identification of the major plant secondary metabolites (PSMs) that might be effective for this pandemic. Our investigation revealed that the proposed plant metabolites can serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development processes to combat COVID-19 and future pandemics caused by viruses. This review will stimulate further analysis by the scientific community and boost antiviral plant-based research followed by novel drug designing.

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Section: Plant-based Antiviral Compounds: Group Basis Mechanism Of Acmentioning

confidence: 99%

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

et al. 2020

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“…According to a review in 2019, acemannan is the major bioactive polysaccharide derived from AV gel [ 49 ]. Acemannan, AV polysaccharides and anthraquinones revealed antiviral activity against the human influenza A virus (H1N1) [ 54 , 55 ]. Hence, acemannan content depends on species and cultivation conditions, irrigation with seawater, harvest season, growth age and solar irradiation intensities [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

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“…To our knowledge, plant‐origin polysaccharides have a considerable number of biological activities, such as anti‐inflammatory, anticancer, and antiviral activities, and the virucidal activity of polysaccharides has been the focus of many research studies. As previously reported, the polysaccharide from L. japonica has anti‐EV71 and anti‐RSV activities, but the detailed mechanisms are unclear.…”

Section: Discussionmentioning

confidence: 88%

“…34 Considering their relatively low cytotoxicity, extracts from traditional Chinese medicines or foods show particular advantages and have attracted increasing attention. 35,36 To our knowledge, plant-origin polysaccharides have a considerable number of biological activities, such as antiinflammatory, 22 anticancer, 21 and antiviral activities, 37,38 and the virucidal activity of polysaccharides has been the focus of many research studies. As previously reported, the polysaccharide from L. japonica has anti-EV71 and anti-RSV 24,39 activities, but the detailed mechanisms are unclear.…”

Section: Discussionmentioning

confidence: 99%

Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infectionin vitro

Cui

Liu

et al. 2020

Microbiology and Immunology

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Enterovirus 71 (EV71) is the predominant pathogen for severe hand, foot, and mouth disease (HFMD) in children younger than 5 years, and currently no effective drugs are available for EV71. Thus, there is an urgent need to develop new drugs for the control of EV71 infection. In this study, LJ04 was extracted from Laminaria japonica using diethylaminoethyl cellulose‐52 with 0.4 mol/l NaCl as the eluent, and its virucidal activity was evaluated based on its cytopathic effects on a microplate. LJ04 is composed of fucose, galactose, and mannose and mainly showed good virucidal activity against EV71. The antiviral mechanisms of LJ04 were the direct inactivation of the virus, the blockage of virus binding, disruptions to viral entry, and weak inhibitory activity against the nonstructural protein 3C. The two most important findings from this study were that LJ04 inhibited EV71 proliferation in HM1900 cells, which are a human microglia cell line, and that LJ04 can directly inactivate EV71 within 2 hr at 37°C. This study demonstrates for the first time the ability of a polysaccharide from L. japonica to inhibit viral and 3C activity; importantly, the inhibition of 3C might have a minor effect on the antiviral effect of LJ04. Consequently, our results identify LJ04 as a potential drug candidate for the control of severe EV71 infection in clinical settings.

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Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug

Cited by 48 publications

References 40 publications

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infectionin vitro

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