Aloe polymannose enhances anti-coxsackievirus antibody titres in mice

Gauntt, Charles J.; Wood, Heidi; McDaniel, H Reginald; McAnalley, Bill H.

doi:10.1002/1099-1573(200006)14:4<261::aid-ptr579>3.0.co;2-a

Cited by 22 publications

(14 citation statements)

References 40 publications

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“…Mannan conjugated to Aβ28 enhanced anti-Aβ antibody production in transgenic mice otherwise hyporesponsive to immunization with Aβ antigen alone [54]. Polymannose purified from the Aloe barbadensis Miller plant enhanced antibody titers against capsid protein epitopes in coxsackievirus B3-immunized mice [55]. Mannose has also been used to better target and enhance the immunogenicity of antigen-containing liposomes.…”

Section: Mannansmentioning

confidence: 99%

Carbohydrate-based immune adjuvants

Petrovsky

Cooper

2011

Expert Review of Vaccines

134

102

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The role for adjuvants in human vaccines has been a matter of vigorous scientific debate, with the field hindered by the fact that for over 80 years, aluminum salts were the only adjuvants approved for human use. To this day, alum-based adjuvants, alone or combined with additional immune activators, remain the only adjuvants approved for use in the USA. This situation has not been helped by the fact that the mechanism of action of most adjuvants has been poorly understood. A relative lack of resources and funding for adjuvant development has only helped to maintain alum’s relative monopoly. To seriously challenge alum’s supremacy a new adjuvant has many major hurdles to overcome, not least being alum’s simplicity, tolerability, safety record and minimal cost. Carbohydrate structures play critical roles in immune system function and carbohydrates also have the virtue of a strong safety and tolerability record. A number of carbohydrate compounds from plant, bacterial, yeast and synthetic sources have emerged as promising vaccine adjuvant candidates. Carbohydrates are readily biodegradable and therefore unlikely to cause problems of long-term tissue deposits seen with alum adjuvants. Above all, the Holy Grail of human adjuvant development is to identify a compound that combines potent vaccine enhancement with maximum tolerability and safety. This has proved to be a tough challenge for many adjuvant contenders. Nevertheless, carbohydrate-based compounds have many favorable properties that could place them in a unique position to challenge alum’s monopoly over human vaccine usage.

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Section: Mannansmentioning

confidence: 99%

Carbohydrate-based immune adjuvants

Petrovsky

Cooper

2011

Expert Review of Vaccines

134

102

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“…The reported therapeutic properties of polysaccharide BRMs are very diverse which include anti-viral [67,170,[195][196][197][198][199], anti-bacterial [7,8], anti-fungal [155,158], anti-parasitic [200][201], and anti-tumor [67,70,72,73,93,[202][203][204][205][206]. However, the therapeutic data are mainly derived from the study of animal models such as mouse [7,8,67,73,95,157,169,170,195,196,200,[203][204][205]207], cat [195], chicken [159] and pig [198] and [208].…”

Section: Clinical Applications Of Brmsmentioning

confidence: 99%

Polysaccharide biological response modifiers

et al. 2006

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“…Aloe polymannose combined with coxsackievirus B3 in a murine model increased Ag-specific antibody production against capsid protein epitopes of non-enveloped picornavirus, compared to the control [112]. The adjuvant effect of mannan-coated liposomes on HIV-1 DNA vaccine was evidenced by the enhanced stimulation of Th1-mediated cellular immune responses [113].…”

Section: Mannan-based Biopolymersmentioning

confidence: 98%

Biodegradable polymers for modern vaccine development

Bose

Kim

Chang

et al. 2019

Journal of Industrial and Engineering Chemistry

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A B S T R A C TMost traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

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Aloe polymannose enhances anti-coxsackievirus antibody titres in mice

Cited by 22 publications

References 40 publications

Carbohydrate-based immune adjuvants

Carbohydrate-based immune adjuvants

Polysaccharide biological response modifiers

Biodegradable polymers for modern vaccine development

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