Aloe-emodin inhibits Staphylococcus aureus biofilms and extracellular protein production at the initial adhesion stage of biofilm development

Xiang, Hua; Cao, Fengjiao; Ming, Di; Zheng, Yanyang; Dong, Xiaoyun; Zhong, Xiaobo; Mu, Dan; Li, Bangbang; Zhong, Ling; Cao, Junsheng; Wang, Lin; Ma, Huiqin; Wang, Tiedong; Wang, Dacheng

doi:10.1007/s00253-017-8403-5

Cited by 86 publications

(51 citation statements)

References 53 publications

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“…Aloin is effective in inflammatory processes, cancer and skin diseases [ 45 ]. Aloin and aloe-emodin inhibited multi-drug resistant S. aureus biofilm formation [ 57 ]. Some major antimicrobial constituents like aloin and aloe-emodin can be increased by the control of climatic, geographical conditions and extraction methods [ 51 , 58 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

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Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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“…Biofilm formation is thought to be a two-step process ( Moormeier and Bayles, 2017 ; Xiang et al, 2017 ). First, the bacteria adhere to the surface, and then they form a complex biofilm architecture.…”

Section: Resultsmentioning

confidence: 99%

Preferential Colonization of Osteoblasts Over Co-cultured Bacteria on a Bifunctional Biomaterial Surface

Chu

Yang

et al. 2018

Front. Microbiol.

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Implant-related infection is a devastating complication in clinical trauma and orthopedics. The aim of this study is to use a bifunctional biomaterial surface in order to investigate the competitive colonization between osteoblasts and bacteria, which is the cause of implant-related infection. A bone-engineering material capable of simultaneously facilitating osteoblast adhesion and inhibiting the growth of Staphylococcus aureus (S. aureus) was prepared. Then, three different co-cultured systems were developed in order to investigate the competitive colonization between the two cohorts on the surface. The results suggested that while the pre-culturing of either cohort compromised the subsequent adhesion of the other according to the ‘race for the surface’ theory, the synergistic effect of preferential cell adhesion and antibacterial activity of the bifunctional surface led to the predominant colonization and survival of osteoblasts, effectively inhibiting the bacterial adhesion and biofilm formation of S. aureus in the co-culture systems with both cohorts. This research offers new insight into the investigation of competitive surface-colonization between osteoblasts and bacteria for implant-related infection.

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“…Based on studies investigating the influence of coating agents on surface adhesion of Staphylococcal sp. on polymer surfaces 31,[35][36][37][38][39] we identified the poloxamer Pluronic F127 as a suitable agent for the reduction of bacterial adhesion in the fluidic channels. Pluronic F127 is a nonionic triblock copolymer composed of hydrophilic outer chains of polyoxyethylene (POE) and a hydrophobic polyoxypropylene (POP) chain in the center.…”

Section: Bacterial Recoverymentioning

confidence: 99%