“…The activity of β-2-(p-biphenyl)ethyl- 3.54ddd (10) 3.80ddd (10.5) 3.74ddd (10.5) 3.86ddd (10) 3.79ddd (10.5) H3 (J 3,4 ) 5.37dd (9.5) 5.32dd (9.5) 5.25dd (9.5) 5.26dd (9.5) 5.37dd (9.5) H4 (J 4,5 ) 4.98dd (9.5) 5.07dd (9.5) 5.05dd (9.5) 5.08dd (9.5) 5.08dd (9.5) H5 (J 5,6a ; J 5,6b ) 3.64ddd (2.5; 5) 3.70ddd ( Cl 3 * MDP (VIId) decreased with a decrease in the immunomodulator dose, whereas that of β-2,2-diphenylethyl-MDP (VIIc) dramatically increased. Previously, we synthesized [16] β-n-(1,1,3,3-tetramethylbutyl)phenyl MDP (VIIg), a glycopeptide with alkylphenyl aglycone also containing 14 carbon atoms; in general, it proved to be more active than glycosides (VIIc) and (VIId). β-2-(Adamant-1-yl)ethyl MDP (VIIb) demonstrated a moderate protective effect, whereas β-4-tertbutylcyclohexyl MDP (VIIa) exhibited the lowest immunostimulating activity among all the compounds.…”