Allyl Phenyl Sulfone

Haynes, Richard K.; Vonwiller, Simone C.

doi:10.1002/047084289x.ra061

Cited by 1 publication

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such an activity difference is more likely to be revealed by comparison of in vitro data, for which differences due to permeation, metabolism, and other pharmacokinetic aspects will be less important. The carba analogue 26 (calculated log P 4.11) of artemether ( 3 ) (calcd log P 3.51) prepared from artemisinic acid, is less active than artemether ( 3 ). Treatment of CQ‐resistant K1 and CQ‐sensitive FC27 strains of P. falciparum with 5 n m artemether ( 3 ) and carba analogue 26 resulted in 100 and 45 % inhibition respectively .…”

Section: Discussionmentioning

confidence: 99%

“…The carba analogue 26 (calculated log P 4.11) of artemether ( 3 ) (calcd log P 3.51) prepared from artemisinic acid, is less active than artemether ( 3 ). Treatment of CQ‐resistant K1 and CQ‐sensitive FC27 strains of P. falciparum with 5 n m artemether ( 3 ) and carba analogue 26 resulted in 100 and 45 % inhibition respectively . Carba analogues of artesunate ( 4 ) are unknown, but compound 27 by way of an approximate structural analogue is equipotent with artemisinin in vitro against the CQ‐resistant W2 and CQ‐sensitive D6 strains, that is, it is some fivefold less active than artesunate .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Methylene Homologues of Artemisone: An Unexpected Structure–Activity Relationship and a Possible Implication for the Design of C10‐Substituted Artemisinins

Cheu

et al. 2016

ChemMedChem

Self Cite

View full text Add to dashboard Cite

We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O‐ and N‐glycosides into more stable C‐glycosides that may possess enhanced biological activities and stabilities. Dihydroartemisinin was converted into 10β‐cyano‐10‐deoxyartemisinin that was hydrolyzed to the α‐primary amide. Reduction of the β‐cyanide and the α‐amide provided the respective methylamine epimers that upon treatment with divinyl sulfone gave the β‐ and α‐methylene homologues, respectively, of artemisone. Surprisingly, the compounds were less active in vitro than artemisone against P. falciparum and displayed no appreciable activity against A549, HCT116, and MCF7 tumor cell lines. This loss in activity may be rationalized in terms of one model for the mechanism of action of artemisinins, namely the cofactor model, wherein the presence of a leaving group at C10 assists in driving hydride transfer from reduced flavin cofactors to the peroxide during perturbation of intracellular redox homeostasis by artemisinins. It is noted that the carba analogue of artemether is less active in vitro than the O‐glycoside parent toward P. falciparum, although extrapolation of such activity differences to other artemisinins at this stage is not possible. However, literature data coupled with the leaving group rationale suggest that artemisinins bearing an amino group attached directly to C10 are optimal compounds.

show abstract

Section: Discussionmentioning

confidence: 99%