Allozyme Variation in the Cotton Mouse (Peromyscus gossypinus)

Boone, James L.; Smith, Michael H.; Laerm, Joshua

doi:10.2307/1383252

Cited by 3 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in each of the remaining datasets, weighted mean F ST values were substantially reduced by the removal of outlying loci (i.e., those that remained statistically significant after correcting for multiple comparisons; Table 2). For example, in P. gossypinus (Boone 1995;Boone et al 1999), the weighted mean F ST was reduced from 0.178 to 0.089 after removing albumin (Alb) and general plasma protein-1 (Pg-1). Similarly, in P. maniculatus (Marquardt 1976), the weighted mean F ST was reduced from 0.050 to 0.019 after removing Alb.…”

Section: Resultsmentioning

confidence: 99%

“…Such information could potentially provide additional insight into the mode of selection responsible for shaping the observed patterns of variation. However, none of the original publications reported significant within-sample departures from Hardy-Weinberg genotypic proportions at any of the candidate genes listed in Table 2 (Selander et al 1971;Marquardt 1976;Smith 1979;Boone 1995Boone , 1999.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Storz

Nachman

2003

Evol

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Storz

Nachman

2003

Evol

View full text Add to dashboard Cite

“…(B) Results from a survey of 24 loci in P. furvus (Harris and Rogers 1999; expected F ST ϭ 0.391). (C) Results from a survey of 37 loci in P. gossypinus (Boone 1995;Boone et al 1999; expected F ST ϭ 0.0.089). Alb and Pg-1 exhibited statistically significant departures from the neutral expectation at an adjusted ␣-level of 0.00135.…”

Section: Discussionmentioning

confidence: 99%

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Storz

Nachman

2003

Evolution

View full text Add to dashboard Cite

Abstract. The effects of natural selection are generally locus-specific, whereas migration, drift, and inbreeding are expected to have relatively uniform effects across the entire genome. This suggests that multilocus surveys of multiple populations can be used to distinguish selection from demographic effects. The purpose of this study was to test for evidence of selection on protein polymorphism in natural populations of mice in the genus Peromyscus. We analyzed published data from geographic surveys of allozyme variation and used a coalescent-based simulation model to identify specific loci that deviated from neutral expectations. Observed F ST values generally exhibited a remarkably close fit to the expected neutral distributions, indicating that the majority of loci are simply tracking stochastic demographic processes. A smaller number of loci exhibited highly significant departures from the expectations of the neutral model and thus appear to be tracking the direct or indirect effects of selection. Most departures from neutrality were characterized by F ST values that far exceeded neutral expectations and were therefore attributable to spatially varying selection. Interestingly, the albumin locus was implicated as a candidate gene for local adaptation in four different species of Peromyscus. The results also demonstrate that selection can severely bias marker-based estimates of neutral parameters.

show abstract

“…The dataset of P. gossypinus contains 70 specimens sampled from four states across the species’ range ( Table 1 ). The geographic sampling was intended to capture first-order variation between mainland phylogeographic groups within the species ( Boone et al. 1999 ; Beckmann 2011 ).…”

Section: Methodsmentioning

confidence: 99%

Mammal Molar Size Ratios and the Inhibitory Cascade at the Intraspecific Scale

Vitek

Roseman

Bloch

2020

Integrative Organismal Biology

View full text Add to dashboard Cite

Mammalian molar crowns form a module in which measurements of size for individual teeth within a toothrow covary with one another. Molar crown size covariation is proposed to fit the inhibitory cascade model (ICM) or its variant the molar module cascade model (MMC), but the inability of the former model to fit across biological scales is a concern in the few cases where it has been tested in Primates. The ICM has thus far failed to explain patterns of intraspecific variation, an intermediate biological scale, even though it explains patterns at both smaller organ-level and larger between-species biological scales. Studies of this topic in a much broader range of taxa are needed, but the properties of a sample appropriate for testing the ICM at the intraspecific level are unclear. Here, we assess intraspecific variation in relative molar sizes of the cotton mouse, Peromyscus gossypinus, to further test the inhibitory cascade model and to develop recommendations for appropriate sampling protocols in future intraspecific studies of molar size variation across Mammalia. To develop these recommendations, we model the sensitivity of estimates of molar ratios to sample size and simulate the use of composite molar rows when complete ones are unavailable. Similar to past studies on primates, our results show that intraspecific variance structure of molar ratios within the rodent P. gossypinus does not meet predictions of the ICM or MMC. When we extend these analyses to include the MMC, one model does not fit observed patterns of variation better than the other. Standing variation in molar size ratios is relatively constant across mammalian samples containing all three molars. In future studies, analyzing average ratio values will require relatively small minimum sample sizes of 2 or more complete molar rows. Even composite-based estimates from four or more specimens per tooth position can accurately estimate mean molar ratios. Analyzing variance structure will require relatively large sample sizes of at least 40-50 complete specimens, and composite molar rows cannot accurately reconstruct variance structure of ratios in a sample. Based on these results we propose guidelines for intraspecific studies of molar size covariation. In particular, we note that the suitability of composite specimens for averaging mean molar ratios is promising for the inclusion of isolated molars and incomplete molar rows from the fossil record in future studies of the evolution of molar modules, as long as variance structure is not a key component of such studies.

show abstract

Allozyme Variation in the Cotton Mouse (Peromyscus gossypinus)

Cited by 3 publications

References 16 publications

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence From Interlocus Contrasts

Mammal Molar Size Ratios and the Inhibitory Cascade at the Intraspecific Scale

Contact Info

Product

Resources

About