The effect of the addition of small amounts of rare-earth elements such as La (0.01 mass%), Y (0.1 mass%), Er (0.1 mass%) and Ce (0.1 mass%) on the refinement of ¢-grains in an ¡+¢-type Ti4.5Al6Nb2Fe2Mo alloy was investigated in the temperature range 1173 1573 K. The ¢-grain size and the rare-earth-oxide precipitates obtained after heat treatment were evaluated using optical microscopy, scanning electron microscopy, and transmission electron microscopy. Upon heating, alloys exhibited rapid ¢-grain growth above a threshold temperature, and this temperature depended on the added rare-earth elements. The fine precipitates of rare-earth oxides formed in the alloy suppressed the ¢-grain growth through pinning. Dissolution of the precipitates in the ¢-matrix caused rapid ¢-grain growth. Yttrium was found to be the most effective element for the suppression of ¢-grain growth at high temperatures such as 1573 K.