1982
DOI: 10.1111/j.1744-313x.1982.tb00969.x
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Allotype and Charge‐related Differences in the Immune Response

Abstract: SUMMARY Rabbits homozygous at the Ab kappa chain allotypic locus (Ab4/Ab4 and Ab9/Ab9) were immunized with negatively and positively charged antigens. The negatively charged antigens were bovine serum albumin (BSA; pI = 4.9), ovalbumin (OV; pI = 4.9) and two synthetic polypeptides: copolymer L‐glutamic acid L‐tyrosine (abbreviated TG; pI = 4.8) and multichain poly (L‐tyrosine: L‐glutamic acid) poly D‐alanine: poly L‐lysine (poly L‐lysine backbone) (abbreviated (TG) ‐ AL; pI = 4.8). The positively charged antig… Show more

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1982
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“…Thus, instead of a relatively simple explanation involving a silent gene, a complicated regulatory mechanism must be invoked, to explain the low penetrance of the Abbus. Phenotypic expression of b4 and b9 allotypic specificities is controlled by difference in electric charges (Szymanska ef al., 198 1;Dubiski & Cinader, 1981;Notenboom et al, 1982). Whether charge also plays a part in the control of expression of Abbus, remains to be seen.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, instead of a relatively simple explanation involving a silent gene, a complicated regulatory mechanism must be invoked, to explain the low penetrance of the Abbus. Phenotypic expression of b4 and b9 allotypic specificities is controlled by difference in electric charges (Szymanska ef al., 198 1;Dubiski & Cinader, 1981;Notenboom et al, 1982). Whether charge also plays a part in the control of expression of Abbus, remains to be seen.…”
Section: Discussionmentioning
confidence: 99%