Allotransplatation of Rat Islets Into the Cisterna Magna of Streptozotocin-Induced Diabetic Rats

Lee, Hyun Chul; Ahn, Kwang Jin; Lim, Sung Kil; Kim, Kyung Rae; Ahn, Young Soo; Lee, Jun Young; Huh, Kap Bum

doi:10.1097/00007890-199203000-00003

Cited by 18 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cerebrum [101] and cisterna magna [102] have both been shown to attenuate hyperglycemia and delay the onset of allograft rejection. However the risk with the brain transplantation site makes this an improbable clinical prospect.…”

Section: Hepatic and Alternative Transplant Sitesmentioning

confidence: 99%

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Pepper

Gala-López

Ziff

et al. 2013

Clinical and Developmental Immunology

136

101

View full text Add to dashboard Cite

Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings.

show abstract

Section: Hepatic and Alternative Transplant Sitesmentioning

confidence: 99%

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Pepper

Gala-López

Ziff

et al. 2013

Clinical and Developmental Immunology

136

101

View full text Add to dashboard Cite

show abstract

“…In study 1, Lewis (inbred, RT1l/RT2a/RT3a) donor to Sprague-Dawley (outbred rats) recipient (L/SD) transplants were used as a first proof of principle. Although other researchers have used outbred SD rats in islet cell transplantation 39 and human neuronal xenotransplantation models, 40 there is potentially greater variability. Therefore in study 2, an aortic transplantation model with inbred ACI (RT1a/RT2b/RT3a) donor to Lewis recipient rats (A/L) 41 was used.…”

Section: Aortic Allograft Transplantationmentioning

confidence: 99%

Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin

et al. 2000

View full text Add to dashboard Cite

show abstract

“…However, little has been published on the islet transplantation in this site. In the past, normoglycemia has been achieved in diabetic rats after syngeneic and allogeneic islet transplantation in the cerebrospinal fluids of cerebral ventricles (1,2) or spinal cord (3). In this study, we investigated glucose homeostasis in diabetic rats after islet transplantation in a subarachnoid cavity surrounding the olfactory bulb.…”

mentioning

confidence: 99%

Islet Transplantation in a Subarachnoid Cavity Surrounding Olfactory Bulb of Diabetic Rats

2013

View full text Add to dashboard Cite

show abstract

Allotransplatation of Rat Islets Into the Cisterna Magna of Streptozotocin-Induced Diabetic Rats

Cited by 18 publications

References 0 publications

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin

Islet Transplantation in a Subarachnoid Cavity Surrounding Olfactory Bulb of Diabetic Rats

Contact Info

Product

Resources

About