2024
DOI: 10.1021/acs.jpcb.4c01703
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Allosteric Cholesterol Site in Glycine Receptors Characterized through Molecular Simulations

Farzaneh Jalalypour,
Rebecca J. Howard,
Erik Lindahl

Abstract: Glycine receptors are pentameric ligand-gated ion channels that conduct chloride ions across postsynaptic membranes to facilitate fast inhibitory neurotransmission. In addition to gating by the glycine agonist, interactions with lipids and other compounds in the surrounding membrane environment modulate their function, but molecular details of these interactions remain unclear, in particular, for cholesterol. Here, we report coarse-grained simulations in a model neuronal membrane for three zebrafish glycine re… Show more

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“…In human serotonin transporter (SERT), cholesterol has been reported to alter the transport activity through the modulation of the conformational dynamics of the protein. , In dopamine transporter (DAT), cholesterol was shown to stabilize the outward-facing conformation, facilitating substrate transport. , A recent report also showed cholesterol-aided allosteric inhibition of substrate transport by lipid inhibitors in the glycine transporter2 (GlyT2) protein . Preferential cholesterol binding to the open and desensitized state over the resting states through specific interaction with the outer-leaflet intersubunit site of zebrafish glycine receptors was also recently reported …”
mentioning
confidence: 99%
“…In human serotonin transporter (SERT), cholesterol has been reported to alter the transport activity through the modulation of the conformational dynamics of the protein. , In dopamine transporter (DAT), cholesterol was shown to stabilize the outward-facing conformation, facilitating substrate transport. , A recent report also showed cholesterol-aided allosteric inhibition of substrate transport by lipid inhibitors in the glycine transporter2 (GlyT2) protein . Preferential cholesterol binding to the open and desensitized state over the resting states through specific interaction with the outer-leaflet intersubunit site of zebrafish glycine receptors was also recently reported …”
mentioning
confidence: 99%