“…We succeeded in designing a type of split AES for sensing adenosine (Yoshida et al, 2006a), IgE and insulin ). Chelyapov and Fletcher et al reported similar sensing systems for AESs (Chelyapov, 2006;Fletcher et al, 2010). Chelyapov used an aptamer that inhibited Russell's viper venom factor X activator (RVV-X), and Fletcher et al used an aptamer that inhibited EcoRI.…”