Allostatic Overload in Patients with Fibromyalgia: Preliminary Findings

Leombruni, Paolo; Zizzi, Francesca; Pavan, Sara; Fusaro, Enrico; Miniotti, Marco

doi:10.1159/000496229

Cited by 8 publications

(4 citation statements)

References 8 publications

(12 reference statements)

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“…A recent preliminary study on female outpatients with fibromyalgia found a prevalence allostatic overload, based on clinimetric criteria, as high as 25% of the sample [265].…”

Section: Musculoskeletal Disordersmentioning

confidence: 97%

Allostatic Load and Its Impact on Health: A Systematic Review

Guidi

Lucente

Sonino

et al. 2020

Psychother Psychosom

593

466

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Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues. Allostatic load is identified by the use of biomarkers and clinical criteria. Objective: To summarize the current knowledge on allostatic load and overload and its clinical implications based on a systematic review of the literature. Methods: PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to December 2019. A manual search of the literature was also performed, and reference lists of the retrieved articles were examined.We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical adult populations. Results: A total of 267 original investigations were included. They encompassed general population studies, as well as clinical studies on consequences of allostatic load/overload on both physical and mental health across a variety of settings. Conclusions: The findings indicate that allostatic load and overload are associated with poorer health outcomes. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine. An integrated approach that includes both biological markers and clinimetric criteria is recommended.

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“…A recent preliminary study on female outpatients with fibromyalgia found a prevalence allostatic overload, based on clinimetric criteria, as high as 25% of the sample [265].…”

Section: Musculoskeletal Disordersmentioning

confidence: 97%

Allostatic Load and Its Impact on Health: A Systematic Review

Guidi

Lucente

Sonino

et al. 2020

Psychother Psychosom

593

466

View full text Add to dashboard Cite

show abstract

“…Compared with other studies, patients undergoing hemodialysis had almost the same proportion in high levels of AL. For example, a recent pilot study found that the percentage of higher AL levels was 25% among female outpatients with fibromyalgia ( Leombruni et al, 2019 ). However, the percentage of high AL levels may vary in different standards of AL.…”

Section: Discussionmentioning

confidence: 99%

A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients

Zhang

Yang

et al. 2022

Front. Physiol.

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Objective: Serum magnesium (Mg2+) levels are associated with insulin resistance, hypertension, lipid abnormalities, and inflammation. However, limited studies have indicated the relationship between Mg2+ and multiple system indexes. The purpose of this study was to investigate the association between Mg2+ and allostatic load (AL) in hemodialysis patients.Methods: A cross-sectional survey was conducted on hemodialysis patients from different centers in Anhui Province, China, between January and December 2020. A total of 3,025 hemodialysis patients were recruited. Their clinical data were measured before hemodialysis. Information was collected by an online self-reported questionnaire and medical record. Serum Mg2+ was divided into three groups by tertiles. A score of AL greater than or equal to 3 was defined as high AL. A binary logistic regression model was applied to examine the relationship between serum Mg2+ and AL.Results: A total of 1,222 patients undergoing hemodialysis were included, 60% of whom were males (733/1,222). The mean (standard deviation) age of patients was 55.90 (12.75). The median level of serum Mg2+ was 1.22 mmol/L. The rate of high AL levels was 23.4%. Serum Mg2+ was negatively correlated with body mass index, fasting blood glucose (Glu), and C-reactive protein and positively correlated with high-density lipoprotein, low-density lipoprotein, total cholesterol, diastolic blood pressure (DBP), and serum phosphorus. After adjusting for gender, anxiety, diabetes, family residence, lipid-lowering agents, antihypertensive medications, albumin, and Glu, the binary logistic regression model showed that patients with lower levels of serum Mg2+ were more likely have high AL (OR for the T1 group of serum Mg2+:1.945, 95% CI: 1.365–2.773, and OR for the T2 group of serum Mg2+:1.556, 95% CI: 1.099–2.201).Conclusion: Our data support the hypothesis that higher serum Mg2+ concentrations may contribute to lower health risk in hemodialysis populations. Further randomized controlled trials and cohort studies are warranted to verify whether Mg2+ supplementation could be part of routine examinations in hemodialysis populations.

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“…Table 2 displays the studies in which the presence of allostatic overload was determined through clinical interviews based on clinimetric criteria in medical settings (Cosci et al, 2020; Guidi et al, 2016; Guidi, Lucente, et al, 2020; Leombruni et al, 2019; Piolanti et al, 2019; Porcelli et al, 2012).…”

Section: The Definition Of Allostatic Overloadmentioning

confidence: 99%

“…There is a strong relationship between stressful life situations and some functional medical disorders, such as neurocirculatory asthenia/atypical chest pain (Sonino et al, 1998). On the basis of clinimetric criteria, a recent preliminary study on female outpatients with fibromyalgia found prevalent allostatic overload in as much as 25% of the sample (Leombruni et al, 2019). If a source of environmental stress is identified, therapeutic measures can have a specific target (Henningsen et al, 2018).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Allostatic Load in Clinical Practice

Fava

Sonino

Lucente

et al. 2022

Clinical Psychological Science

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There is growing awareness of the role of allostatic load (the cost of chronic exposure to fluctuating or heightened physiologic responses resulting from repeated or chronic stress) in the balance between health and disease. When environmental challenges exceed the individual ability to cope, allostatic overload ensues. The determination of allostatic load initially relied on measurements of biomarkers, and then it was expanded to clinimetric criteria for allostatic overload. It provides a characterization of the individual psychosocial environment that is missing from current clinical diagnostic formulations and has major implications for identifying syndromes that are not included in traditional diagnostic classifications. Healthy lifestyle behavior and euthymia may modulate the vulnerabilities induced by allostatic overload. Here, we present a staging system for the longitudinal development of allostatic load. Consideration of allostatic load allows clinicians to create individually tailored interventions to prevent or decrease the negative impact of environmental factors on health.

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Allostatic Overload in Patients with Fibromyalgia: Preliminary Findings

Cited by 8 publications

References 8 publications

Allostatic Load and Its Impact on Health: A Systematic Review

Allostatic Load and Its Impact on Health: A Systematic Review

A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients

Allostatic Load in Clinical Practice

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