Alloreactivity, the Development of the T Cell Repertoire and the Understanding of T Cell Function

Dutton, Richard; Panfili, Peter R.; Swain, Susan L.

doi:10.1111/j.1600-065x.1978.tb00257.x

Cited by 30 publications

(6 citation statements)

References 89 publications

(70 reference statements)

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“…This contrasts with the progressive rise of CTL-P in the spleen, which can be related to the slow increase in percentage of T cells that we have observed in this organ after birth (27,28). Because CTL are T lymphocytes recognizing K and D determinants of the MHC, whereas the GVHR, the assays of helper activity, and the MLC seem to explore the function of T lymphocytes recognizing Ia determinants (29), our observations might correspond to an asynchrony in the maturation of these two subclasses of T lymphocytes, which might correspond to Lyt-2 + and Lyt-2-. In this respect, it is interesting that NB mice are easily tolerized to Ia-encoded determinants of the MHC, but not to K/D (30), which might correspond precisely to a delay in the maturation of the subset of T cells recognizing Ia determinants.…”

Section: Discussionmentioning

confidence: 64%

Post-thymic T lymphocyte maturation during ontogenesis.

Piguet¹,

Irlé²,

Kollatte³

et al. 1981

The Journal of Experimental Medicine

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Peripheral T lymphocytes from newborn (4-6-d-old) mice, isolated from the spleen or lymph nodes, show phenotypic features of immature cortical thymocytes, such as high frequencies of proliferating cells and of peanut lectin-binding cells. These are features of peripheral T cells of recent thymic origin, as shown by in situ labeling of thymocytes and subsequent observation of the migrants to the spleen, which were mainly peanut lectin-binding cells. The function of newborn peripheral T cells was compared, on a per T cell basis, with that of thymocytes and of fully mature peripheral T cells of the adult, using preparations of newborn lymph node cells containing approximately 80% of T lymphocytes. They were strikingly (about 10-fold) less competent than adult T cells in their phytohemagglutinin responsiveness, their capacities to induce a graft vs. host reaction, to proliferate in the mixed lymphocyte reaction, and to help B lymphocytes in a humoral response in vivo and in vitro. In contrast, newborn T lymphocytes were comparable to those of adults in their capacity to generate cytotoxic T lymphocytes. No suppressive effect of newborn T lymphocytes could be demonstrated in several of these assays. These results argue for an asynchronous maturation of two T cell subsets during ontogeny and demonstrate that at least some T lymphocytes leave the thymus as immature T cells resembling cortical thymocytes and further mature at the periphery. Investigation of mice submitted to thymectomy of 5 d of age showed that these incompetent post-thymic T lymphocytes are capable of considerable expansion and maturation in the peripheral lymphoid organs in the absence of a thymic influence.

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Section: Discussionmentioning

confidence: 64%

Post-thymic T lymphocyte maturation during ontogenesis.

Piguet¹,

Irlé²,

Kollatte³

et al. 1981

The Journal of Experimental Medicine

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“…Thus, it was established that there is a triple correlation in which helper T cells are Lytl*2~ and recognize Class 2 MHC antigens while cytotoxic T cells are Lytr2^ and recognize Class 1 MHC antigens. We showed in our earlier experiments that there can be exceptions to the correlation between T cell function and MHC class in the response to foreign MHC alleles (discussed in Dutton et al 1978). In an analysis of these exceptions, we were able to show that the cell surface phenotype of the T cell correlates more faithfully with the class of MHC molecule recognized than with the T cell function.…”

Section: Lyt and Leu Phenotypes And Susceptibility To Moab Blocking Amentioning

confidence: 70%

T Cell Subsets and the Recognition of MHC Class

Swain

1983

Immunological Reviews

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632

254

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We have presented and/or briefly reviewed data which indicates that there are two T cell subsets which interact respectively with the two Classes (1 and 2) of MHC antigen and which can be identified by the Ly (mouse) or Leu (human) molecules that they express. This correlation, and the large body of (largely) circumstantial but still quite convincing data, suggests that these Ly and Leu molecules play a very important role in T cell responses by actually interacting with monomorphic MHC class specific determinants. We suggest that this interaction facilitates and possibly helps direct the binding of the T cell receptor to polymorphic MHC determinants and antigen. In this model T cell "recognition" of MHC and antigen consists of several independent but connected interactions of T cell surface structure with MHC molecules and antigen on antigen-presenting cells or targets.

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“…One problem with this idea, or any other mechanism that proposed extensive mutation in thymus, is that it does not deal with any of the evidence that identical VH gene products are expressed on T cells and B cells specific for the same antigen (Binz & Wigzell 1975, Rajewsky & Eichmann 1977, Dutton et al 1978. A possible way (Doherty & Bennink 1979a) of accommodating ihe VH gene findings in a non-mulalional model is to argue that a small subsel ofthe VH gene products with specificity for, say, influenza virus will also have low affinity for self-MHC glycoproteins expressed an radiation-resistant ihymus cells.…”

Section: The Jerne (1971) Hypothesis Self-tolerance and Mhc Restrictionmentioning

confidence: 99%