Allopurinol-Induced Severe Cutaneous Adverse Drug Reactions: An Analysis of Spontaneous Reports in Malaysia (2000–2018)

Lee, Sing Chet; Wo, Wee Kee; Yeoh, Hee Sheong; Ali, Norleen Mohamed; Hariraj, Vidhya

doi:10.1007/s43441-020-00245-w

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Nonetheless, these medications entail certain adverse effects, including allergies, skin reactions, and liver and kidney impairment. 17,18 Studies indicate that specific food protein-derived peptides play a pivotal role in regulating SUA levels. 24 Dipeptides and tripeptides, compared to standard proteins and amino acids, exhibit heightened bioavailability owing to their reduced hyperosmolarity.…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperuricemia bioactive peptides: a review on obtaining, activity, and mechanism of action

Chen,

Li,

Cai

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Anti-hyperuricemia bioactive peptides: a review on obtaining, activity, and mechanism of action

Chen,

Li,

Cai

et al. 2024

Food Funct.

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“…Currently, there is no cure for gout, and clinical management primarily involves alleviating symptoms using non-steroidal anti-inflammatory drugs [ 8 ], colchicine [ 9 ], and allopurinol [ 10 ]. However, these medications often lead to adverse effects such as diarrhea, abdominal pain, vomiting, rashes, facial edema, gastrointestinal bleeding, hepatitis, and even acute renal failure, severely affecting the physical and mental health as well as the normal life of individuals.…”

Section: Introductionmentioning

confidence: 99%

Antigout effects and mechanisms of total flavonoids from prunus tomentosa

Jiang,

Zhang,

Zhang

et al. 2024

THC

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BACKGROUND: In recent years, hyperuricemia and acute gouty arthritis have become increasingly common, posing a serious threat to public health. Current treatments primarily involve Western medicines with associated toxic side effects. OBJECTIVE: This study aims to investigate the therapeutic effects of total flavones from Prunus tomentosa (PTTF) on a rat model of gout and explore the mechanism of PTTF’s anti-gout action through the TLR4/NF-κB signaling pathway. METHODS: We measured serum uric acid (UA), creatinine (Cr), blood urea nitrogen (BUN), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) levels using an enzyme-linked immunosorbent assay (ELISA). Histopathological changes were observed using HE staining, and the expression levels of relevant proteins were detected through Western blotting. RESULTS: After PTTF treatment, all indicators improved significantly. PTTF reduced blood levels of UA, Cr, BUN, IL-1β, IL-6, and TNF-α, and decreased ankle swelling. CONCLUSIONS: PTTF may have a therapeutic effect on animal models of hyperuricemia and acute gouty arthritis by reducing serum UA levels, improving ankle swelling, and inhibiting inflammation. The primary mechanism involves the regulation of the TLR4/NF-κB signaling pathway to alleviate inflammation. Further research is needed to explore deeper mechanisms.

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“…The current clinical treatment of hyperuricemia primarily relies on pharmacological interventions supplemented by diet and lifestyle modifications. However, prolonged usage of medications aimed at reducing UA levels may lead to adverse effects such as severe allergic reactions and kidney damage (Singer and Wallace, 1986;Lee et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Integrative metabolomic and network pharmacological analysis reveals potential mechanisms of Cardamine circaeoides Hook.f. & Thomson in alleviating potassium oxonate-induced asymptomatic hyperuricemia in rats

Zhu,

Di,

et al. 2023

Front. Pharmacol.

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Cardamine circaeoides Hook.f. & Thomson (CC), a herb of the genus Cardamine (family Brassicaceae), has a rich historical usage in China for both culinary and medicinal purposes. It is distinguished by its remarkable ability to hyperaccumulate selenium (Se). CC has demonstrated efficacy in the prevention of metabolic disorders. However, investigations into the effects of CC on asymptomatic hyperuricemia remain scarce. The objective of this study is to elucidate the mechanism by which CC aqueous extract (CCE) exerts its anti-hyperuricemic effects on asymptomatic hyperuricemic rats induced by potassium oxonate (PO) by integrating metabolomics and network pharmacological analysis. Asymptomatic hyperuricemia was induced by feeding rats with PO (1000 mg/kg) and CCE (0.75, 1.5, or 3 g/kg) once daily for 30 days. Various parameters, including body weight, uric acid (UA) levels, histopathology of renal tissue, and inflammatory factors (IL-1β, IL-6, IL-8, and TNF-α) were assessed. Subsequently, metabolomic analysis of kidney tissues was conducted to explore the effects of CCE on renal metabolites and the related pathways. Furthermore, network pharmacology was employed to explicate the mechanism of action of CCE components identified through UPLC-Q-TOF-MS analysis. Finally, metabolomic and network-pharmacology analyses were performed to predict crucial genes dysregulated in the disease model and rescued by CCE, which were then subjected to verification by RT-qPCR. The findings revealed that CCE significantly inhibited the UA levels from the 21st day to the 30th day. Moreover, CCE exhibited significant inhibition of IL-1β, IL-6, IL-8, and TNF-α levels in renal tissues. The dysregulation of 18 metabolites and the tyrosine, pyrimidine, cysteine, methionine, sphingolipid, and histidine metabolism pathways was prevented by CCE treatment. A joint analysis of targets predicted using the network pharmacology approach and the differential metabolites found in metabolics predicted 8 genes as potential targets of CCE, and 3 of them (PNP gene, JUN gene, and ADA gene) were verified at the mRNA level by RT-qPCR. We conclude that CCE has anti-hyperuricemia effects and alleviates renal inflammation in a rat model of hyperuricemia, and these efficacies are associated with the reversal of increased ADA, PNP, and JUN mRNA expression in renal tissues.

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Allopurinol-Induced Severe Cutaneous Adverse Drug Reactions: An Analysis of Spontaneous Reports in Malaysia (2000–2018)

Cited by 5 publications

References 30 publications

Anti-hyperuricemia bioactive peptides: a review on obtaining, activity, and mechanism of action

Anti-hyperuricemia bioactive peptides: a review on obtaining, activity, and mechanism of action

Antigout effects and mechanisms of total flavonoids from prunus tomentosa

Integrative metabolomic and network pharmacological analysis reveals potential mechanisms of Cardamine circaeoides Hook.f. & Thomson in alleviating potassium oxonate-induced asymptomatic hyperuricemia in rats

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