Allopurinol-Induced Interstitial Nephritis

Systemic Hypersensitivity to Allopurinol with Acute Interstitial Nephritis

“…The present observation confirms a previous report by Gelbart et al [7] and demonstrates that allopurinol may cause acute interstitial nephritis without glomerulone phritis [2,4] or renal vasculitis [1,12]. An allergic mech anism is suggested by the specific reappearance of signs and symptoms upon re-exposure to allopurinol.…”

“…Renal vasculitis [ 1,12], glomerulonephritis [2,4] and acute interstitial nephritis [5,7,13] have been described as part of the hypersensitivity reaction to allopurinol. The present communication describes another case of acute interstitial nephritis following the administration of allo purinol with some unusual clinical features.…”

Nephrotoxicity of gold salts, D-penicillamine, and allopurinol

“…Histopathological examination of renal biopsy or autopsy specimens revealed renal vaseulitis [183], focal segmental glomerulonephritis [186], and acute interstitial nephritis [187,189,191,192]. Jarzobski et al [183] reported a case of the hypersensitivity type of vasculitis with fibrinoid necrosis and eosinophilic reaction, involving multiple organs, especially the kidney, resulting in uremia and death.…”

“…However, no circulating anti-g10merular basement membrane antibody was detected. Acute interstitial nephritis was also induced by the administration of allopurinol [187,189,191,192]. Gelbart el al.…”

Management of Hyperuricemia and Gout

“…Renal insuf fi ciency may occur in the face of allopurinol therapy. Acute interstitial nephritis, focal segmental glomerulonephritis, and vasculitis have all been described in patients treated with allopurinol [706][707][708][709] .…”