Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis
Corey S. Worledge,
Rachael E. Kostelecky,
Liheng Zhou
et al.
Abstract:Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the epithelium relies on for energy procurement. The role of microbiota-sourced purines, such as hypoxanthine, as substrates salvaged by the colonic epithelium for nucleotide biogenesis and energy balance, has recently been appreciated for homeostasis and wound heali… Show more
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