Allopurinol and the risk of prostate cancer in a Finnish population-based cohort

Allopurinol and the risk of prostate cancer

“…Based on the above reviews, we make a hypothesis that there could be a link between allopurinol use, low serum uric acid levels, and prostate cancer, which was partially compatible with our present analysis showing a positive association between prostate cancer and allopurinol use. However, conflicting results exist on current studies 3 4. Further research is needed to clarify this issue.…”

“…The association between allopurinol use and other comorbidities has been widely explored 1 2. Recently one cohort study revealed that no significant association could be detected between allopurinol use and the risk of prostate cancer (HR=1.03; 95% CI 0.92 to 1.16),3 but another cohort study revealed that long-term use of allopurinol for more than 1 year was associated with a lower risk of prostate cancer in men with gout when compared with non-use (HR=0.64; 95% CI 0.45 to 0.90) 4. Some of our ideas were shared with the readers.…”

Drug Repurposing Patent Applications January–March 2020

“…Such correlations can be readily obtained from the literature, but without proof of a causal relationship (which the patent document does not offer), they might be spurious. For example, men chronically treated with allopurinol as a gout treatment may, 36 or may not, 37 have a lower risk of contracting prostate carcinoma, which requires PAICS expression for proliferation and invasion. 38 Similar cases could be made for lung and colon cancer.…”

The association between gout and the risk of urological cancers: A pooled analysis of population‐based studies

“…Some researchers argue that high serum uric acid levels are related to increased risk of cancer, although uric acid was thought to be protective in tumorigenesis because of its systemic antioxidant properties 4 . Recent epidemiological studies report conflicting relationships between gout or gout therapy and the risk of urological cancers, even when analyzing the same databases 1‐3,5‐10 . Given these contradictory reports, we conducted this meta‐analysis to elucidate the risk of urological cancers among individuals with gout.…”

“…4 Recent epidemiological studies report conflicting relationships between gout or gout therapy and the risk of urological cancers, even when analyzing the same databases. [1][2][3][5][6][7][8][9][10] Given these contradictory reports, we con- In conclusion, we observed that individuals with gout appear to have an increased risk of BCa and RCa, but not of PCa. Whether anti-gout medications can play a role in decreasing the risk of urological cancers remains to be further investigated.…”