Allopurinol and Markers of Muscle Damage Among Participants in the Tour de France

Allopurinol prevents cardiac and skeletal muscle damage in professional soccer players

“…Indeed, we observed no differences between placebo and allopurinol‐treated players in their activity profile based on the total distance run/covered, distance covered at high intensity, and distance covered in short sprints, (see http://onlinelibrary.wiley.com/doi/10.1111/sms.12213/suppinfo, for the anthropometric variables and physical activity profiles in our soccer players). These findings are consistent with our previous report on the benefits of allopurinol for cyclists in the Tour de France (Gomez‐Cabrera et al., ).…”

“…We have determined the MDA because it is a reliable indicator of lipid peroxidation in human samples (Breusing et al., ). As previously reported with professional cyclists, allopurinol prevents exercise‐induced lipid peroxidation in soccer players (Gomez‐Cabrera et al., ).…”

Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats

“…An important point related to this enzyme is that we can inhibit it by using a well known, quite safe drug, namely allopurinol which has been used for decades to treat hyperuricemia. Although it has been suggested that allopurinol generates superoxide radical in liver [36] we have previously shown that allopurinol prevents, to a large extent, oxidative stress which occurs in diabetes [5] and in other pathophysiological situations like exhaustive exercise [37]. Other groups confirmed our findings pointing to the important role of xanthine oxidase in the pathophysiology of the disease [6].…”

Impacto do triatlon ironman sobre os parametros de estresse oxidative. DOI:10.5007/1980-0037.2012v14n2p174

“…Similar results were observed in athletes who participated in one of the main ultraendurance cycling races, the Tour de France 27 . Metabolic and muscle wasting in ironman athletes promotes a significant increase in the production of ROS.…”