Alloplastic Replacement of the Urinary Bladder

Rohrmann, Dorothea; Albrecht, Detlef; Hannappel, J.; Gerlach, Roland; Schwarzkopp, Gisela; Lutzeyer, W

doi:10.1016/s0022-5347(01)65442-9

Cited by 53 publications

(11 citation statements)

References 9 publications

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“…These biomaterials have also been associated with in vivo fibrosis and contracture [32]. Synthetic biomaterials in the form of 3D porous foams, meshes, and hydrogels derived from poly-glycolic acid (PGA), poly-L-lactic acid (PLA), copolymers of poly-lactic and -glycolic acid (PLGA) [33–37]; PTFE Teflon [38]; polyether urethane [39]; silicone rubber [40]; and poly(ethylene) glycol (PEG) [41] have also been utilized as platforms for bladder reconstructive strategies. However, permanent synthetic biomaterials routinely demonstrate in vivo mechanical failure and urinary stone formation and thus are limited in clinical applications [42].…”

Section: Conventional Biomaterials For Bladder and Urethral Defect Rementioning

confidence: 99%

Silk Fibroin Scaffolds for Urologic Tissue Engineering

2016

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Urologic tissue engineering efforts have been largely focused on bladder and urethral defect repair. The current surgical gold standard for treatment of poorly compliant pathological bladders and severe urethral stricture disease is enterocystoplasty and onlay urethroplasty with autologous tissue, respectively. The complications associated with autologous tissue use and harvesting have led to efforts to develop tissue-engineered alternatives. Natural and synthetic materials have been used with varying degrees of success, but none has proved consistently reliable for urologic tissue defect repair in humans. Silk fibroin (SF) scaffolds have been tested in bladder and urethral repair because of their favorable biomechanical properties including structural strength, elasticity, biodegradability and biocompatibility. SF scaffolds have been used in multiple animal models, and have demonstrated robust regeneration of smooth muscle and urothelium. The pre-clinical data involving SF scaffolds in urologic defect repair are encouraging and suggest that they hold potential for future clinical use.

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Section: Conventional Biomaterials For Bladder and Urethral Defect Rementioning

confidence: 99%

Silk Fibroin Scaffolds for Urologic Tissue Engineering

2016

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“…Many synthetic materials have been tried in experimental and clinical settings as bladder replacements (such as polyvinyl sponges, tetrafluoroethylene, gelatin scaffolds, collagen matrices, and vicryl matrices). 4,8,25,42,59,70,85 However, these attempts have usually failed because of mechanical, structural, functional, or biocompatibility problems. Also, permanent synthetic materials often succumb to mechanical failure, and urinary stone formation and the use of degradable materials lead to fibroblast deposition, scarring, graft contracture, and a reduced reservoir volume over time.…”

Section: Nanostructured Bladder Materialsmentioning

confidence: 99%

The Role of Nanomedicine in Growing Tissues

Chun

Webster

2009

Ann Biomed Eng

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Nanomedicine (a division of nanotechnology) is an interdisciplinary research field incorporating biology, chemistry, engineering and medicine with the intention to improve disease prevention, diagnosis, and treatment. Specifically, there have been great strides made in using nanomedicine to enhance the functions of cells necessary to regenerate a diverse number of tissues (such as bone, blood vessels, the bladder, teeth, the nervous system, and the heart to name a few). Traditional (micron-structured or nano-smooth) implants suffer from: (i) infection, (ii) inflammation, and (iii) insufficient prolonged bonding between the implanted material and surrounding tissue. To date, such conventional implants have been improved by implementing nanotopographical features on their surfaces. In this review paper, the application of nanomaterials to regenerate numerous organs (including, as specific examples, bone, neural, and bladder tissues) will be presented with necessary future directions highlighted for the field of nanomedicine to progress.

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“…When using cell‐free collagen matrices, scarring and graft contracture may occur over time (69–74). Synthetic materials, which have been tried previously in experimental and clinical settings, include polyvinyl sponge, tetrafluoroethylene (Teflon), collagen matrices, vicryl matrices, and silicone (75–78). Most of the above attempts have usually failed due to mechanical, structural, functional, or biocompatibility problems.…”

Section: Tissue Engineering Of Urologic Structuresmentioning

confidence: 99%

Tissue engineering for the replacement of organ function in the genitourinary system

Atala

2004

American Journal of Transplantation

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Acquired and congenital abnormalities may lead to genitourinary organ damage or loss, requiring eventual reconstruction. Tissue engineering follows the principles of cell transplantation, materials science, and engineering toward the development of biological substitutes that would restore and maintain normal function. Tissue engineering may involve matrices alone, wherein the body's natural ability to regenerate is used to orient or direct new tissue growth, or the use of matrices with cells. Both synthetic and natural biodegradable materials have been used, either alone or as cell delivery vehicles. Tissue engineering has been applied experimentally for the reconstitution of several urologic tissues and organs, including bladder, ureter, urethra, kidney, testis, and genitalia. Fetal applications have also been explored. Recently, several tissue engineering technologies have been used clinically including the use of cells as bulking agents for the treatment of vesicoureteral reflux and incontinence and urethral replacement. Recent progress suggests that engineered genitourinary tissues may have clinical applicability in the future.

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Alloplastic Replacement of the Urinary Bladder

Abstract: The positive outcome of these animal experiments suggests this system would be useful for human bladder substitution. Standardized industrial production of the prostheses will be needed prior to implantation in humans.

Cited by 53 publications

References 9 publications

Silk Fibroin Scaffolds for Urologic Tissue Engineering

Silk Fibroin Scaffolds for Urologic Tissue Engineering

The Role of Nanomedicine in Growing Tissues

Tissue engineering for the replacement of organ function in the genitourinary system

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