Alloplastic Replacement of Canine Trachea with Dacron*

Abstract

Two by two centimeter fenestrations were created in the cervical tracheae of 2 groups of 9 mongrels each during intubation anesthesia. In one group the defect was closed with a Dacron patch of 25 to 50 micron pore-size, while in the other group a Dacron patch of pore-size 125 to 150 micron was inserted. The implant was sealed with 1 ml of fibrin adhesive. Seven dogs of each group were evaluated. Implants made of low-porosity Dacron were not incorporated in any animal, but sloughed into the tracheal lumen. Contrarywise large-pore Dacron underwent connective tissue incorporation in all but one case. As early as 90, and even more so at 270, days granulation tissue rich in fibroblasts and histiocytes had grown into the implant. On the implant, a stroma formed which was epithelialized from the margin already after 90 days. After 200 and 270 days the implant was covered with a respiratory epithelium, however, scattered undifferentiated cells still could be found in its center. Porous prosthetic fabrics when used for partial tracheal replacement can be incorporated by connective tissue and can be epithelialized if the polymer is tissue-compatible, the pore-size of the implant ranges between 120 and 150 micron, the implant is sufficiently stable, and if infection is prevented by fibrin seal.

Reconstruction of Ovine Trachea with a Biomimetic Composite Biomaterial

“…Tracheal specimens from these animals contained traces of a cylindrical ciliated respiratory epithelium on inner surfaces of the implants [ 36 , 37 ]. Kaiser [ 34 ] used porous polyurethane patches to reconstruct small defects in the anterior wall of canine trachea. After 270 days of follow-up, Dacron® patches with 125-250 μ m pore size were incorporated well by the trachea in 6 out of 7 dogs, and their inner surfaces were covered with stratified ciliated epithelium [ 34 ].…”

“…Kaiser [ 34 ] used porous polyurethane patches to reconstruct small defects in the anterior wall of canine trachea. After 270 days of follow-up, Dacron® patches with 125-250 μ m pore size were incorporated well by the trachea in 6 out of 7 dogs, and their inner surfaces were covered with stratified ciliated epithelium [ 34 ]. Also Schauwecker et al [ 38 ] observed good healing of larger circumferential tracheal defects (4 × 4 cm) repaired with polyurethane implants; however, tracheal lumen was obliterated with a newly formed granulation tissue.…”

Comparison of costal cartilage and Dacron® graft in laryngotracheal reconstruction: an experimental study

“…[18] Jacobs and Pordebarac reported that epithelialization of an autogen graft is fully achieved within 3 weeks. [19] The surface of the graft facing the lumen epithelialized rapidly.…”

“…An increase in the diameters of the pores will be helpful for the rapid epithelialization. Kaiser [18] reported that a 2×2 cm defect of canine cervical trachea was closed with a Dacron ® patch having a porosity of 25 to 50 μm or 125 to 150 μm. He observed that the Dacron ® patch with smaller pores was rejected, while the patch with larger pores was covered by connective tissues as quickly as 90 days after the operation.…”

Prefabricated tracheal prosthesis with partial biodegradable materials: a surgical and tissue engineering evaluation in vivo

“…We choose knitted PET for its biocompatibility properties, as previously described by other authors [2,14], provoking limited foreign body reaction, typical of any synthetic material in contact with animal tissues. Knitted Dacron with a high porosity was used, as suggested by Kaiser, which appeared more biocompatible than other forms [18].…”